Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics
Cephalosporins have traditionally been administered as an intermittent infusion. With the knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile, administration via continuous infusion may provide more effective antibiotic exposure for successful therapy. Proposed benefit...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Pharmacy |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2226-4787/12/6/185 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850036727250419712 |
|---|---|
| author | Abbie L. Blunier R. Jake Crocker Rachel Foster Stephanie S. May Caroline E. Powers P. Brandon Bookstaver |
| author_facet | Abbie L. Blunier R. Jake Crocker Rachel Foster Stephanie S. May Caroline E. Powers P. Brandon Bookstaver |
| author_sort | Abbie L. Blunier |
| collection | DOAJ |
| description | Cephalosporins have traditionally been administered as an intermittent infusion. With the knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile, administration via continuous infusion may provide more effective antibiotic exposure for successful therapy. Proposed benefits of administration via continuous infusion include less IV manipulation, decreased potential for antibiotic resistance, and potential cost savings. The objective of this review was to provide a detailed assessment of available evidence for the use of continuous infusion cephalosporins and practical dosing and administration recommendations. Studies were gathered and assessed for inclusion via a literature search of PubMed and Ovid MEDLINE using mesh terms [“continuous infusion” and “cephalosporin”], “intermittent infusion”, [“intermittent versus continuous” and “cephalosporin”], “continuous infusion cephalosporin”, as well as specific drug names. References from included studies were also evaluated for inclusion. Data which compared the two administration methods (continuous infusion vs. intermittent infusion) were evaluated. Thirty-five studies were analyzed among several cephalosporins with variable delivery. Dosing regimens utilized in the selected studies were assessed with known compatibility and stability data and further summarized. |
| format | Article |
| id | doaj-art-e9bed3d24ebb4a46aa19e7bd79bb2944 |
| institution | DOAJ |
| issn | 2226-4787 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmacy |
| spelling | doaj-art-e9bed3d24ebb4a46aa19e7bd79bb29442025-08-20T02:57:04ZengMDPI AGPharmacy2226-47872024-12-0112618510.3390/pharmacy12060185Rationale and Logistics of Continuous Infusion Cephalosporin AntibioticsAbbie L. Blunier0R. Jake Crocker1Rachel Foster2Stephanie S. May3Caroline E. Powers4P. Brandon Bookstaver5Department of Pharmacy, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USADepartment of Pharmacy, Prisma Health Upstate, 701 Grove Rd, Greenville, SC 29605, USADepartment of Pharmacy, Intermountain Medical Center, 5121 South Cottonwood St, Murray, UT 84107, USADepartment of Pharmacy, Intermountain Medical Center, 5121 South Cottonwood St, Murray, UT 84107, USADepartment of Pharmacy, Ralph H. Johnson VA Medical Center, 109 Bee St, Charleston, SC 29401, USADepartment of Pharmacy, Prisma Health Richland, 5 Medical Park Drive, Columbia, SC 29203, USACephalosporins have traditionally been administered as an intermittent infusion. With the knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile, administration via continuous infusion may provide more effective antibiotic exposure for successful therapy. Proposed benefits of administration via continuous infusion include less IV manipulation, decreased potential for antibiotic resistance, and potential cost savings. The objective of this review was to provide a detailed assessment of available evidence for the use of continuous infusion cephalosporins and practical dosing and administration recommendations. Studies were gathered and assessed for inclusion via a literature search of PubMed and Ovid MEDLINE using mesh terms [“continuous infusion” and “cephalosporin”], “intermittent infusion”, [“intermittent versus continuous” and “cephalosporin”], “continuous infusion cephalosporin”, as well as specific drug names. References from included studies were also evaluated for inclusion. Data which compared the two administration methods (continuous infusion vs. intermittent infusion) were evaluated. Thirty-five studies were analyzed among several cephalosporins with variable delivery. Dosing regimens utilized in the selected studies were assessed with known compatibility and stability data and further summarized.https://www.mdpi.com/2226-4787/12/6/185cephalosporinsbeta-lactam antibioticscontinuous infusionpharmacokineticspharmacodynamicsantimicrobial stewardship |
| spellingShingle | Abbie L. Blunier R. Jake Crocker Rachel Foster Stephanie S. May Caroline E. Powers P. Brandon Bookstaver Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics Pharmacy cephalosporins beta-lactam antibiotics continuous infusion pharmacokinetics pharmacodynamics antimicrobial stewardship |
| title | Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics |
| title_full | Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics |
| title_fullStr | Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics |
| title_full_unstemmed | Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics |
| title_short | Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics |
| title_sort | rationale and logistics of continuous infusion cephalosporin antibiotics |
| topic | cephalosporins beta-lactam antibiotics continuous infusion pharmacokinetics pharmacodynamics antimicrobial stewardship |
| url | https://www.mdpi.com/2226-4787/12/6/185 |
| work_keys_str_mv | AT abbielblunier rationaleandlogisticsofcontinuousinfusioncephalosporinantibiotics AT rjakecrocker rationaleandlogisticsofcontinuousinfusioncephalosporinantibiotics AT rachelfoster rationaleandlogisticsofcontinuousinfusioncephalosporinantibiotics AT stephaniesmay rationaleandlogisticsofcontinuousinfusioncephalosporinantibiotics AT carolineepowers rationaleandlogisticsofcontinuousinfusioncephalosporinantibiotics AT pbrandonbookstaver rationaleandlogisticsofcontinuousinfusioncephalosporinantibiotics |