Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China
Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China. Methods. Inpatient medical records of SLE-related AP were retrospectivel...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/568564 |
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| author | Yanlong Yang Yujin Ye Liuqin Liang Tianfu Wu Zhongping Zhan Xiuyan Yang Hanshi Xu |
| author_facet | Yanlong Yang Yujin Ye Liuqin Liang Tianfu Wu Zhongping Zhan Xiuyan Yang Hanshi Xu |
| author_sort | Yanlong Yang |
| collection | DOAJ |
| description | Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China. Methods. Inpatient medical records of SLE-related AP were retrospectively reviewed. Results. 27 out of 4053 SLE patients were diagnosed as SLE-related AP, with an overall prevalence of 0.67%, annual incidence of 0.56‰ and mortality of 37.04%. SLE patients with AP presented with higher SLEDAI score (21.70±10.32 versus 16.17±7.51, P=0.03), more organ systems involvement (5.70±1.56 versus 3.96±1.15, P=0.001), and higher mortality (37.04% versus 0, P=0.001), compared to patients without AP. Severe AP (SAP) patients had a significant higher mortality rate compared to mild AP (MAP) (75% versus 21.05%, P=0.014). 16 SLE-related AP patients received intensive GC treatment, 75% of them exhibited favorable prognosis. Conclusion. SLE-related AP is rare but concomitant with high mortality in South Chinese people, especially in those SAP patients. Activity of SLE, multiple-organ systems involvement may attribute to the severity and mortality of AP. Appropriate glucocorticosteroid (GC) treatment leads to better prognosis in majority of SLE patients with AP. |
| format | Article |
| id | doaj-art-e9bde83b2e4b4aeebac82e2eed7231f0 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e9bde83b2e4b4aeebac82e2eed7231f02025-08-20T02:21:57ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/568564568564Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South ChinaYanlong Yang0Yujin Ye1Liuqin Liang2Tianfu Wu3Zhongping Zhan4Xiuyan Yang5Hanshi Xu6Department of Rheumatology, The 1st Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Rheumatology, The 1st Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Rheumatology, The 1st Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Internal Medicine/Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Rheumatology, The 1st Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Rheumatology, The 1st Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Rheumatology, The 1st Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, ChinaAcute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China. Methods. Inpatient medical records of SLE-related AP were retrospectively reviewed. Results. 27 out of 4053 SLE patients were diagnosed as SLE-related AP, with an overall prevalence of 0.67%, annual incidence of 0.56‰ and mortality of 37.04%. SLE patients with AP presented with higher SLEDAI score (21.70±10.32 versus 16.17±7.51, P=0.03), more organ systems involvement (5.70±1.56 versus 3.96±1.15, P=0.001), and higher mortality (37.04% versus 0, P=0.001), compared to patients without AP. Severe AP (SAP) patients had a significant higher mortality rate compared to mild AP (MAP) (75% versus 21.05%, P=0.014). 16 SLE-related AP patients received intensive GC treatment, 75% of them exhibited favorable prognosis. Conclusion. SLE-related AP is rare but concomitant with high mortality in South Chinese people, especially in those SAP patients. Activity of SLE, multiple-organ systems involvement may attribute to the severity and mortality of AP. Appropriate glucocorticosteroid (GC) treatment leads to better prognosis in majority of SLE patients with AP.http://dx.doi.org/10.1155/2012/568564 |
| spellingShingle | Yanlong Yang Yujin Ye Liuqin Liang Tianfu Wu Zhongping Zhan Xiuyan Yang Hanshi Xu Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China Clinical and Developmental Immunology |
| title | Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China |
| title_full | Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China |
| title_fullStr | Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China |
| title_full_unstemmed | Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China |
| title_short | Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China |
| title_sort | systemic lupus erythematosus related acute pancreatitis a cohort from south china |
| url | http://dx.doi.org/10.1155/2012/568564 |
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