Dynamic alterations of depressive-like behaviors, gut microbiome, and fecal metabolome in social defeat stress mice

Dynamic alterations of depressive-like behaviors, gut microbiome, and fecal metabolome in social defeat stress mice

Abstract Gut microbiome is implicated in the onset and progression of major depressive disorder (MDD), but the dynamic alterations of depressive symptoms, gut microbiome, and fecal metabolome across different stages of stress exposure remain unclear. Here, we modified the chronic social defeat stres...

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Main Authors: Hongrui Li, Ping Liu, Tingfang Sun, Yifan Li, Jing Wu, Yu Huang, Jie Yang, Minghao Yuan, Jianping Zhang, Jian Yang, Ma-Li Wong, Julio Licinio, Peng Zheng
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03326-2
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