Platelet-rich plasma relieves inflammation and pain by regulating M1/M2 macrophage polarization in knee osteoarthritis rats

Platelet-rich plasma relieves inflammation and pain by regulating M1/M2 macrophage polarization in knee osteoarthritis rats

Abstract Knee osteoarthritis (KOA) is a common, chronic, degenerative disease. Platelet-rich plasma (PRP) can significantly relieve KOA pain; however, the mechanism of PRP-induced analgesia remains to be studied. Macrophages are closely related to KOA pain, and regulating macrophage polarization may...

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Bibliographic Details
Main Authors: Jiawei Xu, Xiuping Chen, Haina Zhang, Xiyue Zhang, Rujuan Liu, Xin Li, Junwei Wang, Tieshan Li
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Platelet-rich plasma
Knee osteoarthritis
Macrophages
Pain
NF-κB
Online Access:https://doi.org/10.1038/s41598-025-97501-6
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