Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis
The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of some medicinal plants for SARS-CoV-2 therapy using a systematic review and meta-anal...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2022-06-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2022-0021 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832574006809591808 |
|---|---|
| author | EBENEZER OLUWAKEMI BODEDE OLUSOLA AWOLADE PAUL JORDAAN MARYAM A. OGUNSAKIN ROPO E. SHAPI MICHAEL |
| author_facet | EBENEZER OLUWAKEMI BODEDE OLUSOLA AWOLADE PAUL JORDAAN MARYAM A. OGUNSAKIN ROPO E. SHAPI MICHAEL |
| author_sort | EBENEZER OLUWAKEMI |
| collection | DOAJ |
| description | The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of some medicinal plants for SARS-CoV-2 therapy using a systematic review and meta-analysis of their reported SARS-CoV-1 inhibitory potencies. Relevant data were systematically gathered from three databases, viz., Web of Science, PubMed and Scopus. The information obtained included botanical information, extraction method and extracts concentrations, as well as the proposed mechanisms. Fourteen articles describing 30 different plants met our eligibility criteria. Random effects model and subgroup analysis were applied to investigate heterogeneity. According to subgroup analysis, the substantial heterogeneity of the estimated mean based on the IC50 values reporting the most potent anti-SARS-CoV 3C--like protease (3CLpro) inhibitors (10.07 %, p < 0.0001), was significantly higher compared to the most active anti-SARS-CoV papain-like protease (PLpro) inhibitors (6.12 %, p < 0.0001). More importantly, the literature analysis revealed that fruit extracts of Rheum palmatum L. and the compound cryptotanshinone isolated from the root of Salvia miltiorrhiza (IC50 = 0.8 ± 0.2 μmol L–1) were excellent candidates for anti--SARS-CoV targeting PLpro. Meanwhile, iguesterin (IC50 = 2.6 ± 0.6 μmol L–1) isolated from the bark of Tripterygium regelii emerged as the most excellent candidate for anti-SARS--CoV targeting 3CLpro. The present systematic review and meta-analysis provide valuable and comprehensive information about potential medicinal plants for SARS-CoV-2 inhibition. The chemotypes identified herein can be adopted as a starting point for developing new drugs to contain the novel virus. |
| format | Article |
| id | doaj-art-e9bc270ccf414c2d9b0ceaf884d559ed |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-e9bc270ccf414c2d9b0ceaf884d559ed2025-02-02T01:41:29ZengSciendoActa Pharmaceutica1846-95582022-06-0172219922410.2478/acph-2022-0021Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysisEBENEZER OLUWAKEMI0BODEDE OLUSOLA1AWOLADE PAUL2JORDAAN MARYAM A.3OGUNSAKIN ROPO E.4SHAPI MICHAEL51Faculty of Natural Science, Department of Chemistry, Mangosuthu University of Technology, 511 Mangosuthu HighwayDurban, 4000, South Africa2Department of Agriculture and Animal Health, University of South Africa Florida Campus, Florida, 1710South Africa3School of Chemistry and Physics University of KwaZulu-Natal P/Bag X54001, Westville, DurbanSouth Africa1Faculty of Natural Science, Department of Chemistry, Mangosuthu University of Technology, 511 Mangosuthu HighwayDurban, 4000, South Africa4Discipline of Public Health Medicine College of Health Sciences University of KwaZulu Natal, Durban4001, South Africa1Faculty of Natural Science, Department of Chemistry, Mangosuthu University of Technology, 511 Mangosuthu HighwayDurban, 4000, South AfricaThe novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of some medicinal plants for SARS-CoV-2 therapy using a systematic review and meta-analysis of their reported SARS-CoV-1 inhibitory potencies. Relevant data were systematically gathered from three databases, viz., Web of Science, PubMed and Scopus. The information obtained included botanical information, extraction method and extracts concentrations, as well as the proposed mechanisms. Fourteen articles describing 30 different plants met our eligibility criteria. Random effects model and subgroup analysis were applied to investigate heterogeneity. According to subgroup analysis, the substantial heterogeneity of the estimated mean based on the IC50 values reporting the most potent anti-SARS-CoV 3C--like protease (3CLpro) inhibitors (10.07 %, p < 0.0001), was significantly higher compared to the most active anti-SARS-CoV papain-like protease (PLpro) inhibitors (6.12 %, p < 0.0001). More importantly, the literature analysis revealed that fruit extracts of Rheum palmatum L. and the compound cryptotanshinone isolated from the root of Salvia miltiorrhiza (IC50 = 0.8 ± 0.2 μmol L–1) were excellent candidates for anti--SARS-CoV targeting PLpro. Meanwhile, iguesterin (IC50 = 2.6 ± 0.6 μmol L–1) isolated from the bark of Tripterygium regelii emerged as the most excellent candidate for anti-SARS--CoV targeting 3CLpro. The present systematic review and meta-analysis provide valuable and comprehensive information about potential medicinal plants for SARS-CoV-2 inhibition. The chemotypes identified herein can be adopted as a starting point for developing new drugs to contain the novel virus.https://doi.org/10.2478/acph-2022-0021covid-19 main proteaseinhibitionmedicinal plantssystematic reviewmeta-analysis |
| spellingShingle | EBENEZER OLUWAKEMI BODEDE OLUSOLA AWOLADE PAUL JORDAAN MARYAM A. OGUNSAKIN ROPO E. SHAPI MICHAEL Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis Acta Pharmaceutica covid-19 main protease inhibition medicinal plants systematic review meta-analysis |
| title | Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis |
| title_full | Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis |
| title_fullStr | Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis |
| title_full_unstemmed | Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis |
| title_short | Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis |
| title_sort | medicinal plants with anti sars cov activity repurposing for treatment of covid 19 infection a systematic review and meta analysis |
| topic | covid-19 main protease inhibition medicinal plants systematic review meta-analysis |
| url | https://doi.org/10.2478/acph-2022-0021 |
| work_keys_str_mv | AT ebenezeroluwakemi medicinalplantswithantisarscovactivityrepurposingfortreatmentofcovid19infectionasystematicreviewandmetaanalysis AT bodedeolusola medicinalplantswithantisarscovactivityrepurposingfortreatmentofcovid19infectionasystematicreviewandmetaanalysis AT awoladepaul medicinalplantswithantisarscovactivityrepurposingfortreatmentofcovid19infectionasystematicreviewandmetaanalysis AT jordaanmaryama medicinalplantswithantisarscovactivityrepurposingfortreatmentofcovid19infectionasystematicreviewandmetaanalysis AT ogunsakinropoe medicinalplantswithantisarscovactivityrepurposingfortreatmentofcovid19infectionasystematicreviewandmetaanalysis AT shapimichael medicinalplantswithantisarscovactivityrepurposingfortreatmentofcovid19infectionasystematicreviewandmetaanalysis |