Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic
Mannitol has recently been reported to be effective in enhancing the antinociceptive efficacy of lidocaine. No single study to date, however, has compared diphenhydramine with and without mannitol for nociceptive processing as an alternative local anesthetic. In this study, we examined the antinocic...
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| Language: | English |
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Wiley
2020-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2020/7934164 |
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| author | Jo-Young Son Jae-Seong Lim Jae-Hyung Park Jae-Hyeong Park Myeong-Shin Kim Jung-Ho Park Jun-suk Oh Hyun-Wu Yoon Jin-Sook Ju Dong-Kuk Ahn |
| author_facet | Jo-Young Son Jae-Seong Lim Jae-Hyung Park Jae-Hyeong Park Myeong-Shin Kim Jung-Ho Park Jun-suk Oh Hyun-Wu Yoon Jin-Sook Ju Dong-Kuk Ahn |
| author_sort | Jo-Young Son |
| collection | DOAJ |
| description | Mannitol has recently been reported to be effective in enhancing the antinociceptive efficacy of lidocaine. No single study to date, however, has compared diphenhydramine with and without mannitol for nociceptive processing as an alternative local anesthetic. In this study, we examined the antinociceptive efficacy enhancements of diphenhydramine when combined with mannitol. Male Sprague-Dawley rats weighing 230–260 g were used in a hot plate test to evaluate the antinociceptive effects of diphenhydramine. All chemicals were dissolved in isotonic normal saline and administered subcutaneously into the plantar surface of the right hind paw at 10 min before the hot plate test. A subcutaneous injection of 0.5% or 1% diphenhydramine produced significant inhibition of the withdrawal latency time compared with the vehicle treatment. Antinociceptive effects appeared 10 min after the diphenhydramine injections and persisted for over 30 min. The antinociceptive effects of 1% diphenhydramine were not statistically different from those of 1% lidocaine. Although a subcutaneous injection of a 0.5 M mannitol solution alone did not affect the withdrawal latency time, 1% diphenhydramine with 0.5 M mannitol significantly enhanced antinociception. A subcutaneous injection of 1% diphenhydramine with epinephrine (1 : 100,000) solution did not increase the antinociceptive effect of the diphenhydramine. These results suggest that diphenhydramine with mannitol can be used as an alternative local anesthetic. |
| format | Article |
| id | doaj-art-e9b973c167b24dde99390a357b5e85c5 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Pain Research and Management |
| spelling | doaj-art-e9b973c167b24dde99390a357b5e85c52025-02-03T01:01:34ZengWileyPain Research and Management1203-67651918-15232020-01-01202010.1155/2020/79341647934164Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local AnestheticJo-Young Son0Jae-Seong Lim1Jae-Hyung Park2Jae-Hyeong Park3Myeong-Shin Kim4Jung-Ho Park5Jun-suk Oh6Hyun-Wu Yoon7Jin-Sook Ju8Dong-Kuk Ahn9Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of KoreaMannitol has recently been reported to be effective in enhancing the antinociceptive efficacy of lidocaine. No single study to date, however, has compared diphenhydramine with and without mannitol for nociceptive processing as an alternative local anesthetic. In this study, we examined the antinociceptive efficacy enhancements of diphenhydramine when combined with mannitol. Male Sprague-Dawley rats weighing 230–260 g were used in a hot plate test to evaluate the antinociceptive effects of diphenhydramine. All chemicals were dissolved in isotonic normal saline and administered subcutaneously into the plantar surface of the right hind paw at 10 min before the hot plate test. A subcutaneous injection of 0.5% or 1% diphenhydramine produced significant inhibition of the withdrawal latency time compared with the vehicle treatment. Antinociceptive effects appeared 10 min after the diphenhydramine injections and persisted for over 30 min. The antinociceptive effects of 1% diphenhydramine were not statistically different from those of 1% lidocaine. Although a subcutaneous injection of a 0.5 M mannitol solution alone did not affect the withdrawal latency time, 1% diphenhydramine with 0.5 M mannitol significantly enhanced antinociception. A subcutaneous injection of 1% diphenhydramine with epinephrine (1 : 100,000) solution did not increase the antinociceptive effect of the diphenhydramine. These results suggest that diphenhydramine with mannitol can be used as an alternative local anesthetic.http://dx.doi.org/10.1155/2020/7934164 |
| spellingShingle | Jo-Young Son Jae-Seong Lim Jae-Hyung Park Jae-Hyeong Park Myeong-Shin Kim Jung-Ho Park Jun-suk Oh Hyun-Wu Yoon Jin-Sook Ju Dong-Kuk Ahn Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic Pain Research and Management |
| title | Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic |
| title_full | Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic |
| title_fullStr | Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic |
| title_full_unstemmed | Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic |
| title_short | Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic |
| title_sort | mannitol enhances the antinociceptive effects of diphenhydramine as an alternative local anesthetic |
| url | http://dx.doi.org/10.1155/2020/7934164 |
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