Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes
Objectives. Sclerostin, an osteocyte-specific protein, has been found to be related to adiposity and glucose metabolism. Irisin, a myokine, can affect browning of white fat and influence glucose and energy homeostasis. Taken together, this suggests a probable network among fat, bone, and muscle that...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/261545 |
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| author | Theerawut Klangjareonchai Hataikarn Nimitphong Sunee Saetung Nuttapimon Bhirommuang Rattanapan Samittarucksa Suwannee Chanprasertyothin Rattana Sudatip Boonsong Ongphiphadhanakul |
| author_facet | Theerawut Klangjareonchai Hataikarn Nimitphong Sunee Saetung Nuttapimon Bhirommuang Rattanapan Samittarucksa Suwannee Chanprasertyothin Rattana Sudatip Boonsong Ongphiphadhanakul |
| author_sort | Theerawut Klangjareonchai |
| collection | DOAJ |
| description | Objectives. Sclerostin, an osteocyte-specific protein, has been found to be related to adiposity and glucose metabolism. Irisin, a myokine, can affect browning of white fat and influence glucose and energy homeostasis. Taken together, this suggests a probable network among fat, bone, and muscle that may influence health outcomes. The aims of this study were to investigate the relationship of circulating sclerostin and irisin and their association with adiposity (assessed by body mass index (BMI)). Materials/Methods. A cross-sectional study included 98 adults with impaired fasting glucose and/or impaired glucose tolerance. 75 gm OGTT was performed in all subjects. Fasting plasma samples were obtained for glycated hemoglobin, calcium, creatinine, serum sclerostin and irisin. Results. Circulating irisin and sclerostin were highly correlated (r=-0.4;P<0.001). After controlling for age, gender, and BMI, irisin was significantly related to sclerostin (P<0.001). Multivariate linear regression analysis demonstrated that circulating sclerostin (β=-0.45;P<0.05) and irisin (β=-0.46;P<0.05) were negatively associated with BMI, independent of age in males. In females, no relationship of sclerostin or irisin to BMI was found. Conclusions. Circulating irisin and sclerostin are highly related. Interventions targeting irisin could affect sclerostin and vice versa. |
| format | Article |
| id | doaj-art-e9b63c1fb0d6400b813b84516e9bf875 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e9b63c1fb0d6400b813b84516e9bf8752025-02-03T01:20:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/261545261545Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with PrediabetesTheerawut Klangjareonchai0Hataikarn Nimitphong1Sunee Saetung2Nuttapimon Bhirommuang3Rattanapan Samittarucksa4Suwannee Chanprasertyothin5Rattana Sudatip6Boonsong Ongphiphadhanakul7Department of Medicine and Research Center, Ramathibodi Hospital, Mahidol University, Rama VI Street, Rajathevi, Bangkok 10400, ThailandDepartment of Medicine and Research Center, Ramathibodi Hospital, Mahidol University, Rama VI Street, Rajathevi, Bangkok 10400, ThailandDepartment of Medicine and Research Center, Ramathibodi Hospital, Mahidol University, Rama VI Street, Rajathevi, Bangkok 10400, ThailandDepartment of Medicine and Research Center, Ramathibodi Hospital, Mahidol University, Rama VI Street, Rajathevi, Bangkok 10400, ThailandDepartment of Medicine and Research Center, Ramathibodi Hospital, Mahidol University, Rama VI Street, Rajathevi, Bangkok 10400, ThailandDepartment of Medicine and Research Center, Ramathibodi Hospital, Mahidol University, Rama VI Street, Rajathevi, Bangkok 10400, ThailandDepartment of Medicine and Research Center, Ramathibodi Hospital, Mahidol University, Rama VI Street, Rajathevi, Bangkok 10400, ThailandDepartment of Medicine and Research Center, Ramathibodi Hospital, Mahidol University, Rama VI Street, Rajathevi, Bangkok 10400, ThailandObjectives. Sclerostin, an osteocyte-specific protein, has been found to be related to adiposity and glucose metabolism. Irisin, a myokine, can affect browning of white fat and influence glucose and energy homeostasis. Taken together, this suggests a probable network among fat, bone, and muscle that may influence health outcomes. The aims of this study were to investigate the relationship of circulating sclerostin and irisin and their association with adiposity (assessed by body mass index (BMI)). Materials/Methods. A cross-sectional study included 98 adults with impaired fasting glucose and/or impaired glucose tolerance. 75 gm OGTT was performed in all subjects. Fasting plasma samples were obtained for glycated hemoglobin, calcium, creatinine, serum sclerostin and irisin. Results. Circulating irisin and sclerostin were highly correlated (r=-0.4;P<0.001). After controlling for age, gender, and BMI, irisin was significantly related to sclerostin (P<0.001). Multivariate linear regression analysis demonstrated that circulating sclerostin (β=-0.45;P<0.05) and irisin (β=-0.46;P<0.05) were negatively associated with BMI, independent of age in males. In females, no relationship of sclerostin or irisin to BMI was found. Conclusions. Circulating irisin and sclerostin are highly related. Interventions targeting irisin could affect sclerostin and vice versa.http://dx.doi.org/10.1155/2014/261545 |
| spellingShingle | Theerawut Klangjareonchai Hataikarn Nimitphong Sunee Saetung Nuttapimon Bhirommuang Rattanapan Samittarucksa Suwannee Chanprasertyothin Rattana Sudatip Boonsong Ongphiphadhanakul Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes International Journal of Endocrinology |
| title | Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes |
| title_full | Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes |
| title_fullStr | Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes |
| title_full_unstemmed | Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes |
| title_short | Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes |
| title_sort | circulating sclerostin and irisin are related and interact with gender to influence adiposity in adults with prediabetes |
| url | http://dx.doi.org/10.1155/2014/261545 |
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