Lipoxin and Aspirin-Triggered Lipoxins
Lipoxins and their 15 epimers, aspirin triggered lipoxins (ATL), are eicosanoids derived from sequential lipoxygenase (LO) metabolism of arachidonic acid. The main routes of lipoxin biosynthesis involve cooperation between 15- and 5-LO, and between 12- and 5-LO. ATL are generated by interactions bet...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.113 |
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| author | Mario Romano |
| author_facet | Mario Romano |
| author_sort | Mario Romano |
| collection | DOAJ |
| description | Lipoxins and their 15 epimers, aspirin triggered lipoxins (ATL), are eicosanoids derived from sequential lipoxygenase (LO) metabolism of arachidonic acid. The main routes of lipoxin biosynthesis involve cooperation between 15- and 5-LO, and between 12- and 5-LO. ATL are generated by interactions between 5-LO and aspirin-acetylated cyclooxygenase-2. Cellular models recapitulating these interactions involve leukocytes, platelets, vascular endothelium, and epithelium. To circumvent rapid lipoxin and ATL metabolism and inactivation, stable analogs, bearing potent and long-lasting biological activity, have been synthesized. Some of these analogs displayed therapeutic potential by showing strong anti-inflammatory activity in a number of animal models of disease, including reperfusion injury; arthritis; gastrointestinal, renal, respiratory, and vascular inflammatory disorders; eye damage; periodontitis; and selected infectious diseases. Counter-regulatory signaling by lipoxin A4 and 15-epi-lipoxin A4 is triggered by the activation of a seven-transmembrane domain receptor, termed FPR2/ALX, which is highly expressed in myeloid cells and has been recognized as a main anti-inflammatory receptor. |
| format | Article |
| id | doaj-art-e9b3a298ad3443bfb3b4cfe2c18cfa7d |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e9b3a298ad3443bfb3b4cfe2c18cfa7d2025-08-20T02:21:54ZengWileyThe Scientific World Journal1537-744X2010-01-01101048106410.1100/tsw.2010.113Lipoxin and Aspirin-Triggered LipoxinsMario Romano0Department of Biomedical Sciences, Aging Research Center, Ce.S.I., “Gabriele D'Annunzio” University Foundation, Chieti, ItalyLipoxins and their 15 epimers, aspirin triggered lipoxins (ATL), are eicosanoids derived from sequential lipoxygenase (LO) metabolism of arachidonic acid. The main routes of lipoxin biosynthesis involve cooperation between 15- and 5-LO, and between 12- and 5-LO. ATL are generated by interactions between 5-LO and aspirin-acetylated cyclooxygenase-2. Cellular models recapitulating these interactions involve leukocytes, platelets, vascular endothelium, and epithelium. To circumvent rapid lipoxin and ATL metabolism and inactivation, stable analogs, bearing potent and long-lasting biological activity, have been synthesized. Some of these analogs displayed therapeutic potential by showing strong anti-inflammatory activity in a number of animal models of disease, including reperfusion injury; arthritis; gastrointestinal, renal, respiratory, and vascular inflammatory disorders; eye damage; periodontitis; and selected infectious diseases. Counter-regulatory signaling by lipoxin A4 and 15-epi-lipoxin A4 is triggered by the activation of a seven-transmembrane domain receptor, termed FPR2/ALX, which is highly expressed in myeloid cells and has been recognized as a main anti-inflammatory receptor.http://dx.doi.org/10.1100/tsw.2010.113 |
| spellingShingle | Mario Romano Lipoxin and Aspirin-Triggered Lipoxins The Scientific World Journal |
| title | Lipoxin and Aspirin-Triggered Lipoxins |
| title_full | Lipoxin and Aspirin-Triggered Lipoxins |
| title_fullStr | Lipoxin and Aspirin-Triggered Lipoxins |
| title_full_unstemmed | Lipoxin and Aspirin-Triggered Lipoxins |
| title_short | Lipoxin and Aspirin-Triggered Lipoxins |
| title_sort | lipoxin and aspirin triggered lipoxins |
| url | http://dx.doi.org/10.1100/tsw.2010.113 |
| work_keys_str_mv | AT marioromano lipoxinandaspirintriggeredlipoxins |