Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer
Introduction Tobacco smoking is a major risk factor for various diseases worldwide, including pancreatic exocrine diseases such as pancreatitis and pancreatic cancer (PC). Currently, few studies have examined the impact of smoking cessation on the likelihood of common pancreatic exocrine diseases. T...
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| Format: | Article |
| Language: | English |
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European Publishing
2024-07-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | https://www.tobaccoinduceddiseases.org/Effect-of-smoking-cessation-on-the-likelihood-of-pancreatitis-and-pancreatic-cancer,190635,0,2.html |
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| _version_ | 1832587256174477312 |
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| author | Xiao Han Zouhua Xu Dongmei Ma Zhi Ling Xiaowu Dong Xuebing Yan Yong Chen Guotao Lu Xudong Yin Hongwei Xu |
| author_facet | Xiao Han Zouhua Xu Dongmei Ma Zhi Ling Xiaowu Dong Xuebing Yan Yong Chen Guotao Lu Xudong Yin Hongwei Xu |
| author_sort | Xiao Han |
| collection | DOAJ |
| description | Introduction
Tobacco smoking is a major risk factor for various diseases worldwide,
including pancreatic exocrine diseases such as pancreatitis and pancreatic cancer
(PC). Currently, few studies have examined the impact of smoking cessation
on the likelihood of common pancreatic exocrine diseases. This study sought
to determine whether smoking cessation would reduce pancreatitis and PC
morbidity.
Methods
This cohort study used data from the UK Biobank (UKB) to examine
the association between smoking status and the likelihood of pancreatitis and
PC among 492855 participants. The subjects were divided into never smokers,
ex-smokers, and current smokers. Using a multivariate-adjusted binary logistic
regression model, we analyzed the relationship between different smoking
conditions and the likelihood of pancreatitis and PC. Further, we studied the
impact of smoking cessation on pancreatitis and PC compared with current
smoking.
Results
After adjusting for potential confounders, current smokers had higher odds
for acute pancreatitis (AP) (AOR=1.38; 95% CI: 1.18–1.61), chronic pancreatitis
(CP) (AOR=3.29; 95% CI: 2.35–4.62) and PC (AOR=1.72; 95% CI: 1.42–2.09).
People who quit smoking had comparable odds for the diseases as those who never
smoked. Compared with current smokers, ex-smokers had reduced odds for AP
(AOR=0.76; 95% CI: 0.64–0.89), CP (AOR=0.31; 95% CI: 0.21–0.46), and PC
(AOR=0.62; 95% CI: 0.50–0.76). Subgroup analysis revealed reduced odds for
these pancreatic diseases in males and females.
Conclusions
Smokers have an increased odds for pancreatitis and pancreatic
cancer. Moreover, smoking cessation can significantly reduce the odds for acute
pancreatitis, chronic pancreatitis and pancreatic cancer. |
| format | Article |
| id | doaj-art-e9a14b90c47e402993aaeaf8b2e38dd8 |
| institution | Kabale University |
| issn | 1617-9625 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj-art-e9a14b90c47e402993aaeaf8b2e38dd82025-01-24T15:27:00ZengEuropean PublishingTobacco Induced Diseases1617-96252024-07-0122July1710.18332/tid/190635190635Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancerXiao Han0Zouhua Xu1Dongmei Ma2Zhi Ling3Xiaowu Dong4Xuebing Yan5Yong Chen6Guotao Lu7Xudong Yin8https://orcid.org/0000-0002-9776-1820Hongwei Xu9https://orcid.org/0009-0000-9490-7196Department of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaKunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Yangzhou University, Yangzhou University, Kunshan, ChinaDepartment of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaYangzhou Key Laboratory of Pancreatic Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaYangzhou Key Laboratory of Pancreatic Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaKunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Yangzhou University, Yangzhou University, Kunshan, ChinaIntroduction Tobacco smoking is a major risk factor for various diseases worldwide, including pancreatic exocrine diseases such as pancreatitis and pancreatic cancer (PC). Currently, few studies have examined the impact of smoking cessation on the likelihood of common pancreatic exocrine diseases. This study sought to determine whether smoking cessation would reduce pancreatitis and PC morbidity. Methods This cohort study used data from the UK Biobank (UKB) to examine the association between smoking status and the likelihood of pancreatitis and PC among 492855 participants. The subjects were divided into never smokers, ex-smokers, and current smokers. Using a multivariate-adjusted binary logistic regression model, we analyzed the relationship between different smoking conditions and the likelihood of pancreatitis and PC. Further, we studied the impact of smoking cessation on pancreatitis and PC compared with current smoking. Results After adjusting for potential confounders, current smokers had higher odds for acute pancreatitis (AP) (AOR=1.38; 95% CI: 1.18–1.61), chronic pancreatitis (CP) (AOR=3.29; 95% CI: 2.35–4.62) and PC (AOR=1.72; 95% CI: 1.42–2.09). People who quit smoking had comparable odds for the diseases as those who never smoked. Compared with current smokers, ex-smokers had reduced odds for AP (AOR=0.76; 95% CI: 0.64–0.89), CP (AOR=0.31; 95% CI: 0.21–0.46), and PC (AOR=0.62; 95% CI: 0.50–0.76). Subgroup analysis revealed reduced odds for these pancreatic diseases in males and females. Conclusions Smokers have an increased odds for pancreatitis and pancreatic cancer. Moreover, smoking cessation can significantly reduce the odds for acute pancreatitis, chronic pancreatitis and pancreatic cancer.https://www.tobaccoinduceddiseases.org/Effect-of-smoking-cessation-on-the-likelihood-of-pancreatitis-and-pancreatic-cancer,190635,0,2.htmlsmokingsmoking cessationpancreatitispancreatic cancer |
| spellingShingle | Xiao Han Zouhua Xu Dongmei Ma Zhi Ling Xiaowu Dong Xuebing Yan Yong Chen Guotao Lu Xudong Yin Hongwei Xu Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer Tobacco Induced Diseases smoking smoking cessation pancreatitis pancreatic cancer |
| title | Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer |
| title_full | Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer |
| title_fullStr | Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer |
| title_full_unstemmed | Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer |
| title_short | Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer |
| title_sort | effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer |
| topic | smoking smoking cessation pancreatitis pancreatic cancer |
| url | https://www.tobaccoinduceddiseases.org/Effect-of-smoking-cessation-on-the-likelihood-of-pancreatitis-and-pancreatic-cancer,190635,0,2.html |
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