Photochemical reactions of metal nitrosyl complexes. Mechanisms of NO reactions with biologically relevant metal centers
The discoveries that nitric oxide (a.k.a. nitrogen monoxide) serves important roles in mammalian bioregulation and immunology have stimulated intense interest in the chemistry and biochemistry of NO and derivatives such as metal nitrosyl complexes. Also of interest are strategies to deliver NO to bi...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2001-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/S1110662X01000204 |
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| Summary: | The discoveries that nitric oxide (a.k.a. nitrogen monoxide) serves important roles in mammalian
bioregulation and immunology have stimulated intense interest in the chemistry and biochemistry of NO
and derivatives such as metal nitrosyl complexes. Also of interest are strategies to deliver NO to biological
targets on demand. One such strategy would be to employ a precursor which displays relatively low thermal
reactivity but is photochemically active to release NO. This proposition led us to investigate laser flash
and continuous photolysis kinetics of nitrosyl complexes such as the Roussin's iron-sulfur-nitrosyl cluster
anions Fe2S2(NO)42− and Fe4S3(NO)7− and several ruthenium salen and porphyrin nitrosyls. These include
studies using metal-nitrosyl photochemistry as a vehicle for delivering NO to hypoxic cell cultures in order to
sensitize γ-radiation damage. Also studied were the rates and mechanisms of NO “on” reactions with model
water soluble heme compounds, the ferriheme protein met-myoglobin and various ruthenium complexes
using ns laser flash photolysis techniques. An overview of these studies is presented. |
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| ISSN: | 1110-662X |