Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures
Our knowledge about the consumption of cannabinoids during pregnancy lacks consistent evidence to determine whether it compromises neurodevelopment. Addressing this task is challenging and complex since pregnant women display multiple confounding factors that make it difficult to identify the real e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/2/70 |
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| author | Enrique Estudillo Jorge Iván Castillo-Arellano Emilio Martínez Edgar Rangel-López Adolfo López-Ornelas Roxana Magaña-Maldonado Laura Adalid-Peralta Iván Velasco Itzel Escobedo-Ávila |
| author_facet | Enrique Estudillo Jorge Iván Castillo-Arellano Emilio Martínez Edgar Rangel-López Adolfo López-Ornelas Roxana Magaña-Maldonado Laura Adalid-Peralta Iván Velasco Itzel Escobedo-Ávila |
| author_sort | Enrique Estudillo |
| collection | DOAJ |
| description | Our knowledge about the consumption of cannabinoids during pregnancy lacks consistent evidence to determine whether it compromises neurodevelopment. Addressing this task is challenging and complex since pregnant women display multiple confounding factors that make it difficult to identify the real effect of cannabinoids’ consumption. Recent studies shed light on this issue by using pluripotent stem cells of human origin, which can recapitulate human neurodevelopment. These revolutionary platforms allow studying how exogenous cannabinoids could alter human neurodevelopment without ethical concerns and confounding factors. Here, we review the information to date on the clinical studies about the impact of exogenous cannabinoid consumption on human brain development and how exogenous cannabinoids alter nervous system development in humans using cultured pluripotent stem cells as 2D and 3D platforms to recapitulate brain development. |
| format | Article |
| id | doaj-art-e99759a713af403bb5e8d04fafaf9e14 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-e99759a713af403bb5e8d04fafaf9e142025-01-24T13:26:34ZengMDPI AGCells2073-44092025-01-011427010.3390/cells14020070Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional CulturesEnrique Estudillo0Jorge Iván Castillo-Arellano1Emilio Martínez2Edgar Rangel-López3Adolfo López-Ornelas4Roxana Magaña-Maldonado5Laura Adalid-Peralta6Iván Velasco7Itzel Escobedo-Ávila8Laboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, MexicoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, MexicoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, MexicoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, MexicoDivisión de Investigación, Hospital Juárez de México, Mexico City 07760, MexicoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, MexicoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, MexicoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, MexicoInstituto de Fisiología Celular-Neurociencias, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoOur knowledge about the consumption of cannabinoids during pregnancy lacks consistent evidence to determine whether it compromises neurodevelopment. Addressing this task is challenging and complex since pregnant women display multiple confounding factors that make it difficult to identify the real effect of cannabinoids’ consumption. Recent studies shed light on this issue by using pluripotent stem cells of human origin, which can recapitulate human neurodevelopment. These revolutionary platforms allow studying how exogenous cannabinoids could alter human neurodevelopment without ethical concerns and confounding factors. Here, we review the information to date on the clinical studies about the impact of exogenous cannabinoid consumption on human brain development and how exogenous cannabinoids alter nervous system development in humans using cultured pluripotent stem cells as 2D and 3D platforms to recapitulate brain development.https://www.mdpi.com/2073-4409/14/2/70drugspregnancystem cellscell reprogrammingneurogenesisembryonic development |
| spellingShingle | Enrique Estudillo Jorge Iván Castillo-Arellano Emilio Martínez Edgar Rangel-López Adolfo López-Ornelas Roxana Magaña-Maldonado Laura Adalid-Peralta Iván Velasco Itzel Escobedo-Ávila Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures Cells drugs pregnancy stem cells cell reprogramming neurogenesis embryonic development |
| title | Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures |
| title_full | Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures |
| title_fullStr | Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures |
| title_full_unstemmed | Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures |
| title_short | Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures |
| title_sort | modeling the effect of cannabinoid exposure during human neurodevelopment using bidimensional and tridimensional cultures |
| topic | drugs pregnancy stem cells cell reprogramming neurogenesis embryonic development |
| url | https://www.mdpi.com/2073-4409/14/2/70 |
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