Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1)
Spinocerebellar ataxia type 1 (SCA1) is one of six SCAs related to the expansion of a CAG repeat, encoding glutamine. Induced pluripotent stem cells were generated by reprogramming fibroblasts isolated from a patient affected by SCA1, through the transduction of three viral vectors derived from a no...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506124003350 |
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| author | Mariangela Pappadà Sara Melija Martina Facchini Mara Martino Sofia Minarini Anna Caproni Chiara Nordi Paola Rimessi Rita Selvatici Peggy Marconi |
| author_facet | Mariangela Pappadà Sara Melija Martina Facchini Mara Martino Sofia Minarini Anna Caproni Chiara Nordi Paola Rimessi Rita Selvatici Peggy Marconi |
| author_sort | Mariangela Pappadà |
| collection | DOAJ |
| description | Spinocerebellar ataxia type 1 (SCA1) is one of six SCAs related to the expansion of a CAG repeat, encoding glutamine. Induced pluripotent stem cells were generated by reprogramming fibroblasts isolated from a patient affected by SCA1, through the transduction of three viral vectors derived from a non-integrative virus. UNIFEi001-A cell line presents an ESC-like morphology, is vector-free, expresses pluripotency markers, presents a normal karyotype and can differentiate into the three germ layers. These cells can be further differentiated into neural stem cells and neurons to serve as a cellular model. |
| format | Article |
| id | doaj-art-e99157f2477247fea138389a472d3c24 |
| institution | Kabale University |
| issn | 1873-5061 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj-art-e99157f2477247fea138389a472d3c242025-02-02T05:27:00ZengElsevierStem Cell Research1873-50612025-03-0183103637Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1)Mariangela Pappadà0Sara Melija1Martina Facchini2Mara Martino3Sofia Minarini4Anna Caproni5Chiara Nordi6Paola Rimessi7Rita Selvatici8Peggy Marconi9Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyUnit of Medical Genetics, Department of Medical Sciences, University Hospital of Ferrara, Ferrara, ItalyUnit of Medical Genetics, Department of Medical Sciences, University Hospital of Ferrara, Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy; Technopole of Ferrara, LTTA Laboratory for Advanced Therapies, Ferrara 44121, Italy; Corresponding author.Spinocerebellar ataxia type 1 (SCA1) is one of six SCAs related to the expansion of a CAG repeat, encoding glutamine. Induced pluripotent stem cells were generated by reprogramming fibroblasts isolated from a patient affected by SCA1, through the transduction of three viral vectors derived from a non-integrative virus. UNIFEi001-A cell line presents an ESC-like morphology, is vector-free, expresses pluripotency markers, presents a normal karyotype and can differentiate into the three germ layers. These cells can be further differentiated into neural stem cells and neurons to serve as a cellular model.http://www.sciencedirect.com/science/article/pii/S1873506124003350 |
| spellingShingle | Mariangela Pappadà Sara Melija Martina Facchini Mara Martino Sofia Minarini Anna Caproni Chiara Nordi Paola Rimessi Rita Selvatici Peggy Marconi Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1) Stem Cell Research |
| title | Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1) |
| title_full | Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1) |
| title_fullStr | Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1) |
| title_full_unstemmed | Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1) |
| title_short | Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1) |
| title_sort | generation of a human induced pluripotent stem cell line unifei001 a from a patient with spinocerebellar ataxia type 1 sca1 |
| url | http://www.sciencedirect.com/science/article/pii/S1873506124003350 |
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