Comparison of viral phenotype and inflammatory biomarker responses in acute HIV-1 subtype A and C infections

Comparison of viral phenotype and inflammatory biomarker responses in acute HIV-1 subtype A and C infections

IntroductionHIV-1 subtype A and subtype C infections have different rates of clinical disease progression, with subtype C infected individuals in the IAVI Protocol C multisite acute infection cohort having a 60% faster CD4 loss compared to subtype A.MethodsIn order to investigate whether differences...

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Main Authors: Samantha McInally, Daniel T. Claiborne, Elina El-Badry, Rui Xu, Qianhong Qin, Zachary Ende, Martin J. Deymier, Jake W. Rhodes, Jill Gilmour, William Kilembe, Etienne Karita, Susan A. Allen, Ling Yue, Eric Hunter
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
HIV-1 transmitted founder virus
subtype A
subtype C
replicative capacity
inflammatory chemokines/cytokines
HIV pathogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1649731/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1649731/full

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