Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study
Objectives. Hepatitis B virus (HBV) was believed to have minimal impact on pregnancy outcomes apart from the risk of perinatal transmission. In more recent years, there have been reports of adverse associations, most consistently preterm birth (PTB), but this is in the context of high rates of caesa...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2019/8435019 |
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| author | Marieke Bierhoff Chaisiri Angkurawaranon Aung Myat Min Mary Ellen Gilder Nay Win Tun Arunrot Keereevijitt Aye Kyi Win Elsi Win Verena Ilona Carrara Tobias Brummaier Cindy S. Chu Laurence Thielemans Kanlaya Sriprawat Borimas Hanboonkunupakarn Marcus Rijken François Nosten Michele van Vugt Rose McGready |
| author_facet | Marieke Bierhoff Chaisiri Angkurawaranon Aung Myat Min Mary Ellen Gilder Nay Win Tun Arunrot Keereevijitt Aye Kyi Win Elsi Win Verena Ilona Carrara Tobias Brummaier Cindy S. Chu Laurence Thielemans Kanlaya Sriprawat Borimas Hanboonkunupakarn Marcus Rijken François Nosten Michele van Vugt Rose McGready |
| author_sort | Marieke Bierhoff |
| collection | DOAJ |
| description | Objectives. Hepatitis B virus (HBV) was believed to have minimal impact on pregnancy outcomes apart from the risk of perinatal transmission. In more recent years, there have been reports of adverse associations, most consistently preterm birth (PTB), but this is in the context of high rates of caesarean section. The aim of this study was to explore the association of HBV on pregnancy outcomes in marginalized, low-income populations on the Myanmar-Thailand border. Methods. HBsAg positive (+) point of care rapid detection tests results were confirmed by immunoassays. Women with a confirmed HBsAg status, HIV- and syphilis-negative at first antenatal care screening, singleton fetus and known pregnancy outcome (Aug-2012 to Dec-2016) were included. Logistic regression analysis was used to evaluate associations between HBV group (controls HBsAg negative, HBsAg+/HBeAg-, or HBsAg+/HBeAg+) and pregnancy outcome and comorbidity. Results. Most women were tested, 15,046/15,114 (99.6%) for HBV. The inclusion criteria were not met for 4,089/15,046 (27.2%) women due mainly to unavailability of pregnancy outcome and nonconfirmation of HBsAg+. In evaluable women 687/11,025 (6.2%) were HBsAg+, with 476/11,025 (4.3%) HBsAg+/HBeAg- and 211/11,025 (1.9%) were HBsAg+/HBeAg+. The caesarean section rate was low at 522/8,963 (5.8%). No significant associations were observed between pregnancy comorbidities or adverse pregnancy outcomes and HBV status. Conclusions. The results highlight the disease burden of HBV in women on the Myanmar-Thailand border and support original reports of a lack of significant associations with HBsAg+ irrespective of HBeAg status, for comorbidity, and pregnancy outcomes in deliveries supervised by skilled birth attendants. |
| format | Article |
| id | doaj-art-e9828493caf940f089b44563574f18e6 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-e9828493caf940f089b44563574f18e62025-02-03T05:44:23ZengWileyJournal of Pregnancy2090-27272090-27352019-01-01201910.1155/2019/84350198435019Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort StudyMarieke Bierhoff0Chaisiri Angkurawaranon1Aung Myat Min2Mary Ellen Gilder3Nay Win Tun4Arunrot Keereevijitt5Aye Kyi Win6Elsi Win7Verena Ilona Carrara8Tobias Brummaier9Cindy S. Chu10Laurence Thielemans11Kanlaya Sriprawat12Borimas Hanboonkunupakarn13Marcus Rijken14François Nosten15Michele van Vugt16Rose McGready17Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandDepartment of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok 10400, ThailandUtrecht University Medical Centre, Utrecht, Netherlands, and Julius Centre Global Health, Utrecht 3584 CX, NetherlandsShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandDivision of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, NetherlandsShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, ThailandObjectives. Hepatitis B virus (HBV) was believed to have minimal impact on pregnancy outcomes apart from the risk of perinatal transmission. In more recent years, there have been reports of adverse associations, most consistently preterm birth (PTB), but this is in the context of high rates of caesarean section. The aim of this study was to explore the association of HBV on pregnancy outcomes in marginalized, low-income populations on the Myanmar-Thailand border. Methods. HBsAg positive (+) point of care rapid detection tests results were confirmed by immunoassays. Women with a confirmed HBsAg status, HIV- and syphilis-negative at first antenatal care screening, singleton fetus and known pregnancy outcome (Aug-2012 to Dec-2016) were included. Logistic regression analysis was used to evaluate associations between HBV group (controls HBsAg negative, HBsAg+/HBeAg-, or HBsAg+/HBeAg+) and pregnancy outcome and comorbidity. Results. Most women were tested, 15,046/15,114 (99.6%) for HBV. The inclusion criteria were not met for 4,089/15,046 (27.2%) women due mainly to unavailability of pregnancy outcome and nonconfirmation of HBsAg+. In evaluable women 687/11,025 (6.2%) were HBsAg+, with 476/11,025 (4.3%) HBsAg+/HBeAg- and 211/11,025 (1.9%) were HBsAg+/HBeAg+. The caesarean section rate was low at 522/8,963 (5.8%). No significant associations were observed between pregnancy comorbidities or adverse pregnancy outcomes and HBV status. Conclusions. The results highlight the disease burden of HBV in women on the Myanmar-Thailand border and support original reports of a lack of significant associations with HBsAg+ irrespective of HBeAg status, for comorbidity, and pregnancy outcomes in deliveries supervised by skilled birth attendants.http://dx.doi.org/10.1155/2019/8435019 |
| spellingShingle | Marieke Bierhoff Chaisiri Angkurawaranon Aung Myat Min Mary Ellen Gilder Nay Win Tun Arunrot Keereevijitt Aye Kyi Win Elsi Win Verena Ilona Carrara Tobias Brummaier Cindy S. Chu Laurence Thielemans Kanlaya Sriprawat Borimas Hanboonkunupakarn Marcus Rijken François Nosten Michele van Vugt Rose McGready Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study Journal of Pregnancy |
| title | Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study |
| title_full | Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study |
| title_fullStr | Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study |
| title_full_unstemmed | Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study |
| title_short | Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study |
| title_sort | maternal hepatitis b infection burden comorbidity and pregnancy outcome in a low income population on the myanmar thailand border a retrospective cohort study |
| url | http://dx.doi.org/10.1155/2019/8435019 |
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