Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease
Objectives: Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride metabolism by reversibly inhibiting the lipoprotein lipase activity. Metabolic syndrome (MetS) is an independent risk factor for further cardiovascular disease. This study evaluated the relationship between the fasting serum AN...
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=1;spage=75;epage=81;aulast= |
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| author | Sy-Harn Lian Bang-Gee Hsu Ji-Hung Wang Ming-Chun Chen |
| author_facet | Sy-Harn Lian Bang-Gee Hsu Ji-Hung Wang Ming-Chun Chen |
| author_sort | Sy-Harn Lian |
| collection | DOAJ |
| description | Objectives: Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride metabolism by reversibly inhibiting the lipoprotein lipase activity. Metabolic syndrome (MetS) is an independent risk factor for further cardiovascular disease. This study evaluated the relationship between the fasting serum ANGPTL3 levels and MetS in patients with coronary artery disease (CAD). Materials and Methods: Fasting blood samples were obtained from 90 patients with CAD. Serum ANGPTL3 levels were measured using a commercial enzyme-linked immunosorbent assay kit. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation. Results: Fifty-three patients (58.9%) had MetS. The hypertension (P = 0.001), diabetes (P < 0.001), body weight (P = 0.027), body mass index (P = 0.001), waist circumference (P < 0.001), systolic blood pressure (P = 0.001), fasting glucose (P < 0.001), triglycerides (P < 0.001), blood urea nitrogen (P = 0.044), C-reactive protein (P = 0.010), insulin (P = 0.040), homeostasis model assessment of insulin resistance (P = 0.002), and ANGPTL3 level (P = 0.001) of CAD patients who had MetS were higher, and the high-density lipoprotein cholesterol (P = 0.001) and estimated glomerular filtration rate (P = 0.016) were lower. A binary logistic regression analysis of the significant variables also revealed that the ANGPTL3 level (odds ratio: 1.023, 95% confidence interval: 1.008–1.038, P = 0.002) was an independent predictor of MetS in patients with CAD. Conclusion: The results of our study indicated that the fasting ANGPTL3 level was positively associated with MetS among patients with CAD. |
| format | Article |
| id | doaj-art-e97c98bbdc8e493ca0ccefd155d602de |
| institution | DOAJ |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-e97c98bbdc8e493ca0ccefd155d602de2025-08-20T03:14:13ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562022-01-01341758110.4103/tcmj.tcmj_49_21Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery diseaseSy-Harn LianBang-Gee HsuJi-Hung WangMing-Chun ChenObjectives: Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride metabolism by reversibly inhibiting the lipoprotein lipase activity. Metabolic syndrome (MetS) is an independent risk factor for further cardiovascular disease. This study evaluated the relationship between the fasting serum ANGPTL3 levels and MetS in patients with coronary artery disease (CAD). Materials and Methods: Fasting blood samples were obtained from 90 patients with CAD. Serum ANGPTL3 levels were measured using a commercial enzyme-linked immunosorbent assay kit. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation. Results: Fifty-three patients (58.9%) had MetS. The hypertension (P = 0.001), diabetes (P < 0.001), body weight (P = 0.027), body mass index (P = 0.001), waist circumference (P < 0.001), systolic blood pressure (P = 0.001), fasting glucose (P < 0.001), triglycerides (P < 0.001), blood urea nitrogen (P = 0.044), C-reactive protein (P = 0.010), insulin (P = 0.040), homeostasis model assessment of insulin resistance (P = 0.002), and ANGPTL3 level (P = 0.001) of CAD patients who had MetS were higher, and the high-density lipoprotein cholesterol (P = 0.001) and estimated glomerular filtration rate (P = 0.016) were lower. A binary logistic regression analysis of the significant variables also revealed that the ANGPTL3 level (odds ratio: 1.023, 95% confidence interval: 1.008–1.038, P = 0.002) was an independent predictor of MetS in patients with CAD. Conclusion: The results of our study indicated that the fasting ANGPTL3 level was positively associated with MetS among patients with CAD.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=1;spage=75;epage=81;aulast=angiopoietin-like protein 3coronary artery diseasemetabolic syndrome |
| spellingShingle | Sy-Harn Lian Bang-Gee Hsu Ji-Hung Wang Ming-Chun Chen Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease Tzu Chi Medical Journal angiopoietin-like protein 3 coronary artery disease metabolic syndrome |
| title | Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease |
| title_full | Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease |
| title_fullStr | Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease |
| title_full_unstemmed | Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease |
| title_short | Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease |
| title_sort | positive correlation of serum angiopoietin like protein 3 levels with metabolic syndrome in patients with coronary artery disease |
| topic | angiopoietin-like protein 3 coronary artery disease metabolic syndrome |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=1;spage=75;epage=81;aulast= |
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