Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women
Abdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascular mortality. We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognostic markers perform compared to the state-of-th...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2012/459286 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559802272710656 |
|---|---|
| author | Melanie Ganz Marleen de Bruijne Erik B. Dam Paola Pettersen Morten A. Karsdal Claus Christiansen Mads Nielsen |
| author_facet | Melanie Ganz Marleen de Bruijne Erik B. Dam Paola Pettersen Morten A. Karsdal Claus Christiansen Mads Nielsen |
| author_sort | Melanie Ganz |
| collection | DOAJ |
| description | Abdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascular mortality. We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognostic markers perform compared to the state-of-the-art AC24 marker introduced by Kauppila. Methods. For 308 postmenopausal women, we quantified the number of AAC and the percentage of the abdominal aorta that the lesions occupied in terms of their area, simulated plaque area, thickness, wall coverage, and length. We analysed inter-/intraobserver reproducibility and predictive ability of mortality after 8-9 years via Cox regression leading to hazard ratios (HRs). Results. The coefficient of variation was below 25% for all markers. The strongest individual predictors were the number of calcifications (HR=2.4) and the simulated area percentage (HR=2.96) of a calcified plaque, and, unlike AC24 (HR=1.66), they allowed mortality prediction also after adjusting for traditional risk factors. In a combined Cox regression model, the strongest complementary predictors were the number of calcifications (HR=2.76) and the area percentage (HR=−3.84). Conclusion. Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality. |
| format | Article |
| id | doaj-art-e9762cf4b8a242aaa9a3c37baea230cc |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-e9762cf4b8a242aaa9a3c37baea230cc2025-02-03T01:29:12ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962012-01-01201210.1155/2012/459286459286Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal WomenMelanie Ganz0Marleen de Bruijne1Erik B. Dam2Paola Pettersen3Morten A. Karsdal4Claus Christiansen5Mads Nielsen6Department of Computer Science, University of Copenhagen, 2100 Copenhagen, DenmarkDepartment of Computer Science, University of Copenhagen, 2100 Copenhagen, DenmarkNordic Bioscience Imaging A/S, 2730 Herlev, DenmarkCCBR-Synarc A/S, 2750 Ballerup, DenmarkNordic Bioscience A/S, 2730 Herlev, DenmarkNordic Bioscience A/S, 2730 Herlev, DenmarkDepartment of Computer Science, University of Copenhagen, 2100 Copenhagen, DenmarkAbdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascular mortality. We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognostic markers perform compared to the state-of-the-art AC24 marker introduced by Kauppila. Methods. For 308 postmenopausal women, we quantified the number of AAC and the percentage of the abdominal aorta that the lesions occupied in terms of their area, simulated plaque area, thickness, wall coverage, and length. We analysed inter-/intraobserver reproducibility and predictive ability of mortality after 8-9 years via Cox regression leading to hazard ratios (HRs). Results. The coefficient of variation was below 25% for all markers. The strongest individual predictors were the number of calcifications (HR=2.4) and the simulated area percentage (HR=2.96) of a calcified plaque, and, unlike AC24 (HR=1.66), they allowed mortality prediction also after adjusting for traditional risk factors. In a combined Cox regression model, the strongest complementary predictors were the number of calcifications (HR=2.76) and the area percentage (HR=−3.84). Conclusion. Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.http://dx.doi.org/10.1155/2012/459286 |
| spellingShingle | Melanie Ganz Marleen de Bruijne Erik B. Dam Paola Pettersen Morten A. Karsdal Claus Christiansen Mads Nielsen Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women International Journal of Biomedical Imaging |
| title | Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women |
| title_full | Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women |
| title_fullStr | Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women |
| title_full_unstemmed | Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women |
| title_short | Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women |
| title_sort | distribution size and shape of abdominal aortic calcified deposits and their relationship to mortality in postmenopausal women |
| url | http://dx.doi.org/10.1155/2012/459286 |
| work_keys_str_mv | AT melanieganz distributionsizeandshapeofabdominalaorticcalcifieddepositsandtheirrelationshiptomortalityinpostmenopausalwomen AT marleendebruijne distributionsizeandshapeofabdominalaorticcalcifieddepositsandtheirrelationshiptomortalityinpostmenopausalwomen AT erikbdam distributionsizeandshapeofabdominalaorticcalcifieddepositsandtheirrelationshiptomortalityinpostmenopausalwomen AT paolapettersen distributionsizeandshapeofabdominalaorticcalcifieddepositsandtheirrelationshiptomortalityinpostmenopausalwomen AT mortenakarsdal distributionsizeandshapeofabdominalaorticcalcifieddepositsandtheirrelationshiptomortalityinpostmenopausalwomen AT clauschristiansen distributionsizeandshapeofabdominalaorticcalcifieddepositsandtheirrelationshiptomortalityinpostmenopausalwomen AT madsnielsen distributionsizeandshapeofabdominalaorticcalcifieddepositsandtheirrelationshiptomortalityinpostmenopausalwomen |