Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial

Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial

Abstract Both SARS-CoV-2 mRNA and mucosal vaccines induce protective immunity against COVID-19 but showed different immune profiles. We conducted a longitudinal head-to-head analysis of the safety and immunogenicity of the aerosolized adenovirus-vectored and mRNA COVID-19 vaccines. 450 participants...

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Main Authors: Shipo Wu, Jianying Huang, Busen Wang, Jianhua Li, Jianyuan Wu, Zhe Zhang, Lin Luo, Jinlong Zhang, Nan Huo, Jianglan Long, He Huang, Zhengshan Chen, Mengyao Zhang, Zhenghao Zhao, Junyan Dan, Xiaohong Song, Haiyan Mao, Shengyuan Huo, Hao Yan, Yanjun Zhang, Xinghuan Wang, Lihua Hou
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62698-7
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