A novel organoid model retaining the glioma microenvironment for personalized drug screening and therapeutic evaluation

A novel organoid model retaining the glioma microenvironment for personalized drug screening and therapeutic evaluation

Glioma is an aggressive brain tumor with a poor prognosis. Establishing an in vitro culture model that closely replicates the cellular composition and microenvironment of the original tumor has been challenging, limiting its clinical applications. Here, we present a novel approach to generate glioma...

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Bibliographic Details
Main Authors: Chengjun Zheng, Peng Wang, Delong Zhang, Zheng Fang, Yutong Feng, Jie Chen, Jiahong Chen, Yiwen Fu, Bao Yang, Shuqing Yu, Li Min, Bo Xiao, Cencan Xing, Yang Yang, Jianfeng Wang, Donghua Zou, Shipeng Ning, Tong Liu, Jun Yan, Qian Zhao, Fei Sun, Qiaodong Chen, Ying Zhang, Tao Jiang, Lemin Zheng, Zhaoshi Bao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Bioactive Materials
Subjects:
Glioma
Organoid
Matrigel
Tumor microenvironment
Drug screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25003081
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