Non-albicans Candida Infection: An Emerging Threat
The very nature of infectious diseases has undergone profound changes in the past few decades. Fungi once considered as nonpathogenic or less virulent are now recognized as a primary cause of morbidity and mortality in immunocompromised and severely ill patients. Candida spp. are among the most comm...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2014/615958 |
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| author | Sachin C. Deorukhkar Santosh Saini Stephen Mathew |
| author_facet | Sachin C. Deorukhkar Santosh Saini Stephen Mathew |
| author_sort | Sachin C. Deorukhkar |
| collection | DOAJ |
| description | The very nature of infectious diseases has undergone profound changes in the past few decades. Fungi once considered as nonpathogenic or less virulent are now recognized as a primary cause of morbidity and mortality in immunocompromised and severely ill patients. Candida spp. are among the most common fungal pathogens. Candida albicans was the predominant cause of candidiasis. However, a shift toward non-albicans Candida species has been recently observed. These non-albicans Candida species demonstrate reduced susceptibility to commonly used antifungal drugs. In the present study, we investigated the prevalence of non-albicans Candida spp. among Candida isolates from various clinical specimens and analysed their virulence factors and antifungal susceptibility profile. A total of 523 Candida spp. were isolated from various clinical specimens. Non-albicans Candida species were the predominant pathogens isolated. Non-albicans Candida species also demonstrated the production of virulence factors once attributed to Candida albicans. Non-albicans Candida demonstrated high resistance to azole group of antifungal agents. Therefore, it can be concluded that non-albicans Candida species have emerged as an important cause of infections. Their isolation from clinical specimen can no longer be ignored as a nonpathogenic isolate nor can it be dismissed as a contaminant. |
| format | Article |
| id | doaj-art-e9630656c99543ff927040a094722e28 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-e9630656c99543ff927040a094722e282025-02-03T01:27:41ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982014-01-01201410.1155/2014/615958615958Non-albicans Candida Infection: An Emerging ThreatSachin C. Deorukhkar0Santosh Saini1Stephen Mathew2Department of Microbiology, Rural Medical College, Pravara Institute of Medical Sciences (Deemed University), Loni, Maharashtra 413736, IndiaDepartment of Microbiology, Rural Medical College, Pravara Institute of Medical Sciences (Deemed University), Loni, Maharashtra 413736, IndiaDepartment of Microbiology, Rural Medical College, Pravara Institute of Medical Sciences (Deemed University), Loni, Maharashtra 413736, IndiaThe very nature of infectious diseases has undergone profound changes in the past few decades. Fungi once considered as nonpathogenic or less virulent are now recognized as a primary cause of morbidity and mortality in immunocompromised and severely ill patients. Candida spp. are among the most common fungal pathogens. Candida albicans was the predominant cause of candidiasis. However, a shift toward non-albicans Candida species has been recently observed. These non-albicans Candida species demonstrate reduced susceptibility to commonly used antifungal drugs. In the present study, we investigated the prevalence of non-albicans Candida spp. among Candida isolates from various clinical specimens and analysed their virulence factors and antifungal susceptibility profile. A total of 523 Candida spp. were isolated from various clinical specimens. Non-albicans Candida species were the predominant pathogens isolated. Non-albicans Candida species also demonstrated the production of virulence factors once attributed to Candida albicans. Non-albicans Candida demonstrated high resistance to azole group of antifungal agents. Therefore, it can be concluded that non-albicans Candida species have emerged as an important cause of infections. Their isolation from clinical specimen can no longer be ignored as a nonpathogenic isolate nor can it be dismissed as a contaminant.http://dx.doi.org/10.1155/2014/615958 |
| spellingShingle | Sachin C. Deorukhkar Santosh Saini Stephen Mathew Non-albicans Candida Infection: An Emerging Threat Interdisciplinary Perspectives on Infectious Diseases |
| title | Non-albicans Candida Infection: An Emerging Threat |
| title_full | Non-albicans Candida Infection: An Emerging Threat |
| title_fullStr | Non-albicans Candida Infection: An Emerging Threat |
| title_full_unstemmed | Non-albicans Candida Infection: An Emerging Threat |
| title_short | Non-albicans Candida Infection: An Emerging Threat |
| title_sort | non albicans candida infection an emerging threat |
| url | http://dx.doi.org/10.1155/2014/615958 |
| work_keys_str_mv | AT sachincdeorukhkar nonalbicanscandidainfectionanemergingthreat AT santoshsaini nonalbicanscandidainfectionanemergingthreat AT stephenmathew nonalbicanscandidainfectionanemergingthreat |