Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets
Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modified with coffee husks (CH-CPE). Scanning electron microscopy (SEM) and SEM-energy dispersive X-ray spectroscopy (SEM-EDX) were, respectively, used for the morphological and elem...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Electrochemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/1953278 |
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| author | Serge Foukmeniok Mbokou Maxime Pontié Jean-Philippe Bouchara Francis Merlin Melataguia Tchieno Evangeline Njanja Assad Mogni Pierre Yves Pontalier Ignas Kenfack Tonle |
| author_facet | Serge Foukmeniok Mbokou Maxime Pontié Jean-Philippe Bouchara Francis Merlin Melataguia Tchieno Evangeline Njanja Assad Mogni Pierre Yves Pontalier Ignas Kenfack Tonle |
| author_sort | Serge Foukmeniok Mbokou |
| collection | DOAJ |
| description | Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modified with coffee husks (CH-CPE). Scanning electron microscopy (SEM) and SEM-energy dispersive X-ray spectroscopy (SEM-EDX) were, respectively, used for the morphological and elemental characterization of coffee husks prior to their utilization. The electrochemical oxidation of APAP was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). SWV technique appeared to be more sensitive since the oxidation current of APAP was twofold higher with the CH-CPE sensor than with the bare CPE, in relation to the increase in the organophilic character of the electrode surface. Furthermore, on CH-CPE, the current response of APAP varied linearly with its concentration in the range of 6.6 μM to 0.5 mM, leading to a detection limit of 0.66 μM (S/N=3). Finally, the proposed CH-CPE sensor was successfully used to determine the amount of APAP in commercialized tablets (Doliprane® 500 and Doliprane 1000), with a recovery rate ranging from 98% to 103%. This novel sensor opens the way for the development of low-cost and reliable devices for the electroanalysis of pharmaceutical formulations in developing countries. |
| format | Article |
| id | doaj-art-e962988a843f4cf4b47c92540c2f88c5 |
| institution | Kabale University |
| issn | 2090-3529 2090-3537 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Electrochemistry |
| spelling | doaj-art-e962988a843f4cf4b47c92540c2f88c52025-02-03T01:01:12ZengWileyInternational Journal of Electrochemistry2090-35292090-35372016-01-01201610.1155/2016/19532781953278Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical TabletsSerge Foukmeniok Mbokou0Maxime Pontié1Jean-Philippe Bouchara2Francis Merlin Melataguia Tchieno3Evangeline Njanja4Assad Mogni5Pierre Yves Pontalier6Ignas Kenfack Tonle7Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, CameroonL’UNAM, University of Angers, GEPEA UMR-CNRS 6144, 2 boulevard Lavoisier, 49045 Angers, FranceL’UNAM, University of Angers, GEIHP EA 3142, Institut de Biologie en Santé-IRIS, CHU, 4 rue Larrey, 49933 Angers, FranceElectrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, CameroonElectrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, CameroonUniversité de Toulouse, INP-ENSIACET, Laboratoire de Chimie Agro-Industrielle (LCA), 31030 Toulouse, FranceUniversité de Toulouse, INP-ENSIACET, Laboratoire de Chimie Agro-Industrielle (LCA), 31030 Toulouse, FranceElectrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, CameroonElectrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modified with coffee husks (CH-CPE). Scanning electron microscopy (SEM) and SEM-energy dispersive X-ray spectroscopy (SEM-EDX) were, respectively, used for the morphological and elemental characterization of coffee husks prior to their utilization. The electrochemical oxidation of APAP was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). SWV technique appeared to be more sensitive since the oxidation current of APAP was twofold higher with the CH-CPE sensor than with the bare CPE, in relation to the increase in the organophilic character of the electrode surface. Furthermore, on CH-CPE, the current response of APAP varied linearly with its concentration in the range of 6.6 μM to 0.5 mM, leading to a detection limit of 0.66 μM (S/N=3). Finally, the proposed CH-CPE sensor was successfully used to determine the amount of APAP in commercialized tablets (Doliprane® 500 and Doliprane 1000), with a recovery rate ranging from 98% to 103%. This novel sensor opens the way for the development of low-cost and reliable devices for the electroanalysis of pharmaceutical formulations in developing countries.http://dx.doi.org/10.1155/2016/1953278 |
| spellingShingle | Serge Foukmeniok Mbokou Maxime Pontié Jean-Philippe Bouchara Francis Merlin Melataguia Tchieno Evangeline Njanja Assad Mogni Pierre Yves Pontalier Ignas Kenfack Tonle Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets International Journal of Electrochemistry |
| title | Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets |
| title_full | Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets |
| title_fullStr | Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets |
| title_full_unstemmed | Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets |
| title_short | Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets |
| title_sort | electroanalytical performance of a carbon paste electrode modified by coffee husks for the quantification of acetaminophen in quality control of commercialized pharmaceutical tablets |
| url | http://dx.doi.org/10.1155/2016/1953278 |
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