Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains

Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains

Abstract Background Pig brains serve as a valuable biomedical model for studying brain-related diseases due to their significant structural similarities to the human brain. Furthermore, the long-term domestication and artificial selection of domestic pigs have profoundly shaped their brains, making...

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Main Authors: Yue Xiang, Saixian Zhang, Yi Huang, Zhuqing Zheng, Jiahui Sun, Qiulin Zhao, Peng Zhou, Xiaolong Qi, Jingjin Li, Fuyang Xiong, Jing Xu, Shengquan Wang, Liangliang Fu, Xinyun Li
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Biology
Subjects:
Pigs
Brain
ScATAC-seq
Cis-regulatory elements
Biomedical models
Online Access:https://doi.org/10.1186/s12915-025-02263-2
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