Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical Formulation
Two selective and sensitive spectrophotometric methods have been developed for the estimation of adefovir dipivoxil in bulk and pharmaceutical preparations. Adefovir dipivoxil was subjected to acid hydrolysis and the hydrolysed product used for the estimation. The methods are based on the reaction w...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/954232 |
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| author | Zaheer Ahmed Y. N. Manohara K. P. Channabasawaraj Manish Majumdar |
| author_facet | Zaheer Ahmed Y. N. Manohara K. P. Channabasawaraj Manish Majumdar |
| author_sort | Zaheer Ahmed |
| collection | DOAJ |
| description | Two selective and sensitive spectrophotometric methods have been developed for the estimation of adefovir dipivoxil in bulk and pharmaceutical preparations. Adefovir dipivoxil was subjected to acid hydrolysis and the hydrolysed product used for the estimation. The methods are based on the reaction with 3-methyl-2-benzothiazolinone hydrazone in the presence of ferric chloride, to form a colored species with absorption maxima at 627 nm. The second method is based on the reaction of drug with 1,2 naphthaquinone -4-sulphonic acid sodium salt, under alkaline conditions which absorbs maximally at 454 nm. Beers law is obeyed in the concentration range of 5-25 µg/mL and 2-10 µg/mL respectively. These methods were extended to pharmaceutical formulations and there was no interference from excepients and diluents. The analytical parameters were evaluated. |
| format | Article |
| id | doaj-art-e95b82278254470c82e190edb3796825 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-e95b82278254470c82e190edb37968252025-02-03T07:25:59ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015471371710.1155/2008/954232Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical FormulationZaheer Ahmed0Y. N. Manohara1K. P. Channabasawaraj2Manish Majumdar3Department of Pharmaceutical Analysis, National College of Pharmacy, Shimoga–577201(KS) , IndiaDepartment of Pharmaceutical Analysis, National College of Pharmacy, Shimoga–577201(KS) , IndiaDepartment of Pharmaceutical Analysis, National College of Pharmacy, Shimoga–577201(KS) , IndiaDepartment of Pharmaceutical Analysis, National College of Pharmacy, Shimoga–577201(KS) , IndiaTwo selective and sensitive spectrophotometric methods have been developed for the estimation of adefovir dipivoxil in bulk and pharmaceutical preparations. Adefovir dipivoxil was subjected to acid hydrolysis and the hydrolysed product used for the estimation. The methods are based on the reaction with 3-methyl-2-benzothiazolinone hydrazone in the presence of ferric chloride, to form a colored species with absorption maxima at 627 nm. The second method is based on the reaction of drug with 1,2 naphthaquinone -4-sulphonic acid sodium salt, under alkaline conditions which absorbs maximally at 454 nm. Beers law is obeyed in the concentration range of 5-25 µg/mL and 2-10 µg/mL respectively. These methods were extended to pharmaceutical formulations and there was no interference from excepients and diluents. The analytical parameters were evaluated.http://dx.doi.org/10.1155/2008/954232 |
| spellingShingle | Zaheer Ahmed Y. N. Manohara K. P. Channabasawaraj Manish Majumdar Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical Formulation E-Journal of Chemistry |
| title | Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical Formulation |
| title_full | Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical Formulation |
| title_fullStr | Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical Formulation |
| title_full_unstemmed | Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical Formulation |
| title_short | Spectrophotometric Determination of Adefovir Dipivoxil in bulk and Pharmaceutical Formulation |
| title_sort | spectrophotometric determination of adefovir dipivoxil in bulk and pharmaceutical formulation |
| url | http://dx.doi.org/10.1155/2008/954232 |
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