Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2

Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2

Increasing spread by SARS-CoV-2 Omicron variants challenges existing vaccines and broadly reactive neutralizing antibodies (bNAbs) against COVID-19. Here we determine the diversity, potency, breadth and structural insights of bNAbs derived from memory B cells of BNT162b2-vaccinee after homogeneous O...

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Bibliographic Details
Main Authors: Mengxiao Luo, Biao Zhou, Eswar R. Reddem, Bingjie Tang, Bohao Chen, Runhong Zhou, Hang Liu, Lihong Liu, Phinikoula S. Katsamba, Ka-Kit Au, Hiu-On Man, Kelvin Kai-Wang To, Kwok-Yung Yuen, Lawrence Shapiro, Shangyu Dang, David D. Ho, Zhiwei Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
Omicron BA.1 breakthrough infection
hybrid immunity
broadly neutralizing antibody
memory B cell
structural basis of antibody
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2022.2146538
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