Melittin alleviates bleomycin-induced pulmonary fibrosis in vivo through regulating TGF-β1/Smad2/3 and AMPK/SIRT1/PGC-1α signaling pathways

Melittin alleviates bleomycin-induced pulmonary fibrosis in vivo through regulating TGF-β1/Smad2/3 and AMPK/SIRT1/PGC-1α signaling pathways

Objective(s): The present study investigated the protective effect of melittin (MEL) against bleomycin (BLM)- induced pulmonary fibrosis (PF) in mice and the mechanism underlying this effect.Materials and Methods: A mouse model of PF was established by intratracheal injection of 3.5 mg/kg BLM. Twent...

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Bibliographic Details
Main Authors:	Jiawang Yu, WeiHua Lu
Format:	Article
Language:	English
Published:	Mashhad University of Medical Sciences 2025-04-01
Series:	Iranian Journal of Basic Medical Sciences
Subjects:	epithelial-mesenchymal transition melittin mitochondria oxidative stress pulmonary fibrosis
Online Access:	https://ijbms.mums.ac.ir/article_25234_24d3e1f5d2b477da45b0cfcccbb31afb.pdf
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