Mesoporous silica loaded with calcitonin gene-related peptide antagonist and curcumin alleviate oxidative stress and inflammation in the sciatic nerve

Mesoporous silica loaded with calcitonin gene-related peptide antagonist and curcumin alleviate oxidative stress and inflammation in the sciatic nerve

BackgroundNeuropathic pain (NP) is a kind of chronic pain that can lead to neurasthenia. The effectiveness of current drug treatment for NP is still unsatisfactory due to its side effects, addiction and withdrawal. In recent years, researchers have begun to develop nano-drug delivery systems for the...

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Bibliographic Details
Main Authors: Yi Zhu, Zhuoliang Zhang, Liangliang Gao, Yue Tian, Xinyu Lu, Yinhong Jiang, Huibin Su, Chengyong Gu, Chenghuan Shi, Lei Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
CGRP antagonist
curcumin
mesoporous materials
nanoparticles
neuropathic pain
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1510141/full
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