Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population
Objective. Sodium intake is associated with cardiovascular outcomes. However, no study has specifically reported an association between cardiovascular mortality and urinary sodium concentration (UNa). We examined the association of UNa with mortality in a cohort of type 2 diabetes (T2D) patients. Me...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/5327352 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553434910294016 |
|---|---|
| author | Pierre-Jean Saulnier Elise Gand Stéphanie Ragot Lise Bankir Xavier Piguel Frédéric Fumeron Vincent Rigalleau Jean-Michel Halimi Richard Marechaud Ronan Roussel Samy Hadjadj SURDIAGENE Study group |
| author_facet | Pierre-Jean Saulnier Elise Gand Stéphanie Ragot Lise Bankir Xavier Piguel Frédéric Fumeron Vincent Rigalleau Jean-Michel Halimi Richard Marechaud Ronan Roussel Samy Hadjadj SURDIAGENE Study group |
| author_sort | Pierre-Jean Saulnier |
| collection | DOAJ |
| description | Objective. Sodium intake is associated with cardiovascular outcomes. However, no study has specifically reported an association between cardiovascular mortality and urinary sodium concentration (UNa). We examined the association of UNa with mortality in a cohort of type 2 diabetes (T2D) patients. Methods. Patients were followed for all-cause death and cardiovascular death. Baseline UNa was measured from second morning spot urinary sample. We used Cox proportional hazard models to identify independent predictors of mortality. Improvement in prediction of mortality by the addition of UNa to a model including known risk factors was assessed by the relative integrated discrimination improvement (rIDI) index. Results. Participants (n=1,439) were followed for a median of 5.7 years, during which 254 cardiovascular deaths and 429 all-cause deaths were recorded. UNa independently predicted all-cause and cardiovascular mortality. An increase of one standard deviation of UNa was associated with a decrease of 21% of all-cause mortality and 22% of cardiovascular mortality. UNa improved all-cause and cardiovascular mortality prediction beyond identified risk factors (rIDI = 2.8%, P=0.04 and rIDI = 4.6%, P=0.02, resp.). Conclusions. In T2D, UNa was an independent predictor of mortality (low concentration is associated with increased risk) and improved modestly its prediction in addition to traditional risk factors. |
| format | Article |
| id | doaj-art-e94590ea30c243cdac915c7649b5dae2 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e94590ea30c243cdac915c7649b5dae22025-02-03T05:54:09ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/53273525327352Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort PopulationPierre-Jean Saulnier0Elise Gand1Stéphanie Ragot2Lise Bankir3Xavier Piguel4Frédéric Fumeron5Vincent Rigalleau6Jean-Michel Halimi7Richard Marechaud8Ronan Roussel9Samy Hadjadj10SURDIAGENE Study group11CHU de Poitiers, Centre d’Investigation Clinique, Poitiers, FranceCHU Poitiers, Pole DUNE, Poitiers, FranceCHU de Poitiers, Centre d’Investigation Clinique, Poitiers, FranceInserm, UMRS1138, Centre de Recherche des Cordeliers, Paris, FranceCHU Poitiers, Pole DUNE, Poitiers, FranceInserm, UMRS1138, Centre de Recherche des Cordeliers, Paris, FranceCHU Bordeaux, Service d’Endocrinologie, Diabétologie, Maladies Métaboliques et Nutrition, Bordeaux, FranceCHU Tours, Service de Néphrologie, Tours, FranceCHU Poitiers, Pole DUNE, Poitiers, FranceInserm, UMRS1138, Centre de Recherche des Cordeliers, Paris, FranceCHU de Poitiers, Centre d’Investigation Clinique, Poitiers, FranceCHU de Poitiers, Centre d’Investigation Clinique, Poitiers, FranceObjective. Sodium intake is associated with cardiovascular outcomes. However, no study has specifically reported an association between cardiovascular mortality and urinary sodium concentration (UNa). We examined the association of UNa with mortality in a cohort of type 2 diabetes (T2D) patients. Methods. Patients were followed for all-cause death and cardiovascular death. Baseline UNa was measured from second morning spot urinary sample. We used Cox proportional hazard models to identify independent predictors of mortality. Improvement in prediction of mortality by the addition of UNa to a model including known risk factors was assessed by the relative integrated discrimination improvement (rIDI) index. Results. Participants (n=1,439) were followed for a median of 5.7 years, during which 254 cardiovascular deaths and 429 all-cause deaths were recorded. UNa independently predicted all-cause and cardiovascular mortality. An increase of one standard deviation of UNa was associated with a decrease of 21% of all-cause mortality and 22% of cardiovascular mortality. UNa improved all-cause and cardiovascular mortality prediction beyond identified risk factors (rIDI = 2.8%, P=0.04 and rIDI = 4.6%, P=0.02, resp.). Conclusions. In T2D, UNa was an independent predictor of mortality (low concentration is associated with increased risk) and improved modestly its prediction in addition to traditional risk factors.http://dx.doi.org/10.1155/2017/5327352 |
| spellingShingle | Pierre-Jean Saulnier Elise Gand Stéphanie Ragot Lise Bankir Xavier Piguel Frédéric Fumeron Vincent Rigalleau Jean-Michel Halimi Richard Marechaud Ronan Roussel Samy Hadjadj SURDIAGENE Study group Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population Journal of Diabetes Research |
| title | Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population |
| title_full | Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population |
| title_fullStr | Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population |
| title_full_unstemmed | Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population |
| title_short | Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population |
| title_sort | urinary sodium concentration is an independent predictor of all cause and cardiovascular mortality in a type 2 diabetes cohort population |
| url | http://dx.doi.org/10.1155/2017/5327352 |
| work_keys_str_mv | AT pierrejeansaulnier urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT elisegand urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT stephanieragot urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT lisebankir urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT xavierpiguel urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT fredericfumeron urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT vincentrigalleau urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT jeanmichelhalimi urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT richardmarechaud urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT ronanroussel urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT samyhadjadj urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation AT surdiagenestudygroup urinarysodiumconcentrationisanindependentpredictorofallcauseandcardiovascularmortalityinatype2diabetescohortpopulation |