Influence of Nanoparticle Content and Cross-Linking Degree on Functional Attributes of Calcium Alginate-ZnO Nanocomposite Wound Dressings
Alginate-ZnO nanoparticles (ZnO<sub>nano</sub>) composite wound dressing membranes were prepared with two different ZnO<sub>nano</sub> concentrations (0.03 and 0.20 g ZnO/g sodium alginate) and cross-linked with two different calcium treatments (low and high Ca<sup>++&l...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/15/4/108 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Alginate-ZnO nanoparticles (ZnO<sub>nano</sub>) composite wound dressing membranes were prepared with two different ZnO<sub>nano</sub> concentrations (0.03 and 0.20 g ZnO/g sodium alginate) and cross-linked with two different calcium treatments (low and high Ca<sup>++</sup>concentration) to evaluate the influence of nanoparticle content and cross-linking degree on membrane attributes. ZnO<sub>nano</sub> addition did not significantly alter the mechanical properties, water vapor permeability, swelling degree in water and the alginate amorphous nature of the nanocomposite membranes. The increase in cross-linking degree, on the other hand, altered the microstructure of the membranes, increased the tensile strength and reduced the water vapor permeability of the nanocomposite membranes. The presence of ZnO<sub>nano</sub> in alginate membranes granted them antibacterial activity in vitro against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> and substantially increased the absorption capacity in phosphate buffer and fetal bovine serum solutions, validating their potential use as wound dressings. |
|---|---|
| ISSN: | 2077-0375 |