Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats
This study was aimed at investigating the effect of ethanol on oral bioavailability of kaempferol in rats, namely, at disclosing their possible interaction. Kaempferol (100 or 250 mg kg-1 bm) was administered to the rats by oral gavage with or without ethanol (600 mg kg-1 bm) co-administration. Intr...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0044 |
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| author | Zhou Zhaoxiang Wang Meng Guo Zengjun Zhang Xiaoying |
| author_facet | Zhou Zhaoxiang Wang Meng Guo Zengjun Zhang Xiaoying |
| author_sort | Zhou Zhaoxiang |
| collection | DOAJ |
| description | This study was aimed at investigating the effect of ethanol on oral bioavailability of kaempferol in rats, namely, at disclosing their possible interaction. Kaempferol (100 or 250 mg kg-1 bm) was administered to the rats by oral gavage with or without ethanol (600 mg kg-1 bm) co-administration. Intravenous administration (10 and 25 mg kg-1 bm) of kaempferol was used to determine the bioavailability. The concentration of kaempferol in plasma was estimated by ultra high performance liquid chromatography. During coadministration, a significant increase of the area under the plasma concentration-time curve as well as the peak concentration were observed, along with a dramatic decrease in total body clearance. Consequently, the bioavailability of kaempferol in oral control groups was 3.1 % (100 mg kg-1 bm) and 2.1 % (250 mg kg-1 bm). The first was increased by 4.3 % and the other by 2.8 % during ethanol co-administration. Increased permeability of cell membrane and ethanolkaempferol interactions on CYP450 enzymes may enhance the oral bioavailability of kaempferol in rats. |
| format | Article |
| id | doaj-art-e93e8ece4f924b27b632a6fbc8a11208 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-e93e8ece4f924b27b632a6fbc8a112082025-02-02T11:59:26ZengSciendoActa Pharmaceutica1846-95582016-12-0166456356810.1515/acph-2016-0044acph-2016-0044Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in ratsZhou Zhaoxiang0Wang Meng1Guo Zengjun2Zhang Xiaoying3College of Veterinary Medicine Northwest A&F University, Yangling Shaanxi 712100, ChinaCollege of Veterinary Medicine Northwest A&F University, Yangling Shaanxi 712100, ChinaSchool of Pharmacy Xi’an Jiaotong University Xi’an Shaanxi 710061, ChinaCollege of Veterinary Medicine Northwest A&F University, Yangling Shaanxi 712100, ChinaThis study was aimed at investigating the effect of ethanol on oral bioavailability of kaempferol in rats, namely, at disclosing their possible interaction. Kaempferol (100 or 250 mg kg-1 bm) was administered to the rats by oral gavage with or without ethanol (600 mg kg-1 bm) co-administration. Intravenous administration (10 and 25 mg kg-1 bm) of kaempferol was used to determine the bioavailability. The concentration of kaempferol in plasma was estimated by ultra high performance liquid chromatography. During coadministration, a significant increase of the area under the plasma concentration-time curve as well as the peak concentration were observed, along with a dramatic decrease in total body clearance. Consequently, the bioavailability of kaempferol in oral control groups was 3.1 % (100 mg kg-1 bm) and 2.1 % (250 mg kg-1 bm). The first was increased by 4.3 % and the other by 2.8 % during ethanol co-administration. Increased permeability of cell membrane and ethanolkaempferol interactions on CYP450 enzymes may enhance the oral bioavailability of kaempferol in rats.https://doi.org/10.1515/acph-2016-0044kaempferolbioavailabilitypharmacokineticsethanolcytochrome p450s |
| spellingShingle | Zhou Zhaoxiang Wang Meng Guo Zengjun Zhang Xiaoying Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats Acta Pharmaceutica kaempferol bioavailability pharmacokinetics ethanol cytochrome p450s |
| title | Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats |
| title_full | Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats |
| title_fullStr | Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats |
| title_full_unstemmed | Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats |
| title_short | Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats |
| title_sort | pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats |
| topic | kaempferol bioavailability pharmacokinetics ethanol cytochrome p450s |
| url | https://doi.org/10.1515/acph-2016-0044 |
| work_keys_str_mv | AT zhouzhaoxiang pharmacokineticevaluationoftheinteractionbetweenoralkaempferolandethanolinrats AT wangmeng pharmacokineticevaluationoftheinteractionbetweenoralkaempferolandethanolinrats AT guozengjun pharmacokineticevaluationoftheinteractionbetweenoralkaempferolandethanolinrats AT zhangxiaoying pharmacokineticevaluationoftheinteractionbetweenoralkaempferolandethanolinrats |