Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions
We report a case of multiple myoepithelioma with synchronous bone and soft tissue tumors, associated with a new genomic alteration of the LPP locus. The lesions occurred in the foot by presenting one lump in the plantar soft tissue, and three lesions were detected in the calcaneus and in the navicul...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/3512847 |
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| author | Géraldine Pairet Gaëlle Tilman Rafaël Sciot Thomas Schubert Vasiliki Perlepe Hélène A. Poirel Christine Galant |
| author_facet | Géraldine Pairet Gaëlle Tilman Rafaël Sciot Thomas Schubert Vasiliki Perlepe Hélène A. Poirel Christine Galant |
| author_sort | Géraldine Pairet |
| collection | DOAJ |
| description | We report a case of multiple myoepithelioma with synchronous bone and soft tissue tumors, associated with a new genomic alteration of the LPP locus. The lesions occurred in the foot by presenting one lump in the plantar soft tissue, and three lesions were detected in the calcaneus and in the navicular bone. All tumors showed the double immunophenotype of epithelial markers and S100 protein expression. No rearrangement of the EWSR1 and FUS loci was detected as reported in myoepitheliomas. However, molecular karyotyping detected an unbalanced rearrangement of the LPP locus, not involving the HMGA2 locus, which is the most frequent translocation partner observed in benign mesenchymal tumors such as lipomas (of soft tissue as well as parosteal) and pulmonary chondroid hamartoma. |
| format | Article |
| id | doaj-art-e937bd1fc3b840b69c09ec65c86b27a8 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-e937bd1fc3b840b69c09ec65c86b27a82025-02-03T05:58:43ZengWileyCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/35128473512847Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue LesionsGéraldine Pairet0Gaëlle Tilman1Rafaël Sciot2Thomas Schubert3Vasiliki Perlepe4Hélène A. Poirel5Christine Galant6Department of Pathology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumCenter for Human Genetics, Cliniques Universitaires Saint-Luc–Université catholique de Louvain, Brussels, BelgiumDepartment of Pathology, Katholieke Universiteit Leuven, Leuven, BelgiumDepartment of Orthopaedic Surgery, Cliniques Universitaires Saint-Luc, Brussels, BelgiumDepartment of Medical Imaging, Cliniques Universitaires St-Luc, Brussels, BelgiumCenter for Human Genetics, Cliniques Universitaires Saint-Luc and Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, Brussels, BelgiumDepartment of Pathology, Cliniques Universitaires St-Luc and IREC, Pôle de morphologie MORF, Université Catholique de Louvain, Brussels, BelgiumWe report a case of multiple myoepithelioma with synchronous bone and soft tissue tumors, associated with a new genomic alteration of the LPP locus. The lesions occurred in the foot by presenting one lump in the plantar soft tissue, and three lesions were detected in the calcaneus and in the navicular bone. All tumors showed the double immunophenotype of epithelial markers and S100 protein expression. No rearrangement of the EWSR1 and FUS loci was detected as reported in myoepitheliomas. However, molecular karyotyping detected an unbalanced rearrangement of the LPP locus, not involving the HMGA2 locus, which is the most frequent translocation partner observed in benign mesenchymal tumors such as lipomas (of soft tissue as well as parosteal) and pulmonary chondroid hamartoma.http://dx.doi.org/10.1155/2018/3512847 |
| spellingShingle | Géraldine Pairet Gaëlle Tilman Rafaël Sciot Thomas Schubert Vasiliki Perlepe Hélène A. Poirel Christine Galant Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions Case Reports in Oncological Medicine |
| title | Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions |
| title_full | Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions |
| title_fullStr | Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions |
| title_full_unstemmed | Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions |
| title_short | Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions |
| title_sort | case reports in oncological medicine myoepithelioma a new rearrangement involving the lpp locus in a case of multiple bone and soft tissue lesions |
| url | http://dx.doi.org/10.1155/2018/3512847 |
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