A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke
Neural stem cells (NSCs) offer a potential therapeutic benefit in the recovery from ischemic stroke. Understanding the role of endogenous neural stem and progenitor cells under normal physiological conditions aids in analyzing their effects after ischemic injury, including their impact on functional...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/3267352 |
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| author | Cesar Reis Michael Wilkinson Haley Reis Onat Akyol Vadim Gospodarev Camila Araujo Sheng Chen John H. Zhang |
| author_facet | Cesar Reis Michael Wilkinson Haley Reis Onat Akyol Vadim Gospodarev Camila Araujo Sheng Chen John H. Zhang |
| author_sort | Cesar Reis |
| collection | DOAJ |
| description | Neural stem cells (NSCs) offer a potential therapeutic benefit in the recovery from ischemic stroke. Understanding the role of endogenous neural stem and progenitor cells under normal physiological conditions aids in analyzing their effects after ischemic injury, including their impact on functional recovery and neurogenesis at the site of injury. Recent animal studies have utilized unique subsets of exogenous and endogenous stem cells as well as preconditioning with pharmacologic agents to better understand the best situation for stem cell proliferation, migration, and differentiation. These stem cell therapies provide a promising effect on stimulation of endogenous neurogenesis, neuroprotection, anti-inflammatory effects, and improved cell survival rates. Clinical trials performed using various stem cell types show promising results to their safety and effectiveness on reducing the effects of ischemic stroke in humans. Another important aspect of stem cell therapy discussed in this review is tracking endogenous and exogenous NSCs with magnetic resonance imaging. This review explores the pathophysiology of NSCs on ischemic stroke, stem cell therapy studies and their effects on neurogenesis, the most recent clinical trials, and techniques to track and monitor the progress of endogenous and exogenous stem cells. |
| format | Article |
| id | doaj-art-e934b1e24e1843d8b0f97c37ebb3b365 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e934b1e24e1843d8b0f97c37ebb3b3652025-02-03T06:00:24ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/32673523267352A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic StrokeCesar Reis0Michael Wilkinson1Haley Reis2Onat Akyol3Vadim Gospodarev4Camila Araujo5Sheng Chen6John H. Zhang7Department of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall, Room 219, Loma Linda, CA 92354, USALoma Linda University School of Medicine, Loma Linda, CA 92354, USALoma Linda University School of Medicine, Loma Linda, CA 92354, USADepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall, Room 219, Loma Linda, CA 92354, USADepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall, Room 219, Loma Linda, CA 92354, USADepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall, Room 219, Loma Linda, CA 92354, USADepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall, Room 219, Loma Linda, CA 92354, USANeural stem cells (NSCs) offer a potential therapeutic benefit in the recovery from ischemic stroke. Understanding the role of endogenous neural stem and progenitor cells under normal physiological conditions aids in analyzing their effects after ischemic injury, including their impact on functional recovery and neurogenesis at the site of injury. Recent animal studies have utilized unique subsets of exogenous and endogenous stem cells as well as preconditioning with pharmacologic agents to better understand the best situation for stem cell proliferation, migration, and differentiation. These stem cell therapies provide a promising effect on stimulation of endogenous neurogenesis, neuroprotection, anti-inflammatory effects, and improved cell survival rates. Clinical trials performed using various stem cell types show promising results to their safety and effectiveness on reducing the effects of ischemic stroke in humans. Another important aspect of stem cell therapy discussed in this review is tracking endogenous and exogenous NSCs with magnetic resonance imaging. This review explores the pathophysiology of NSCs on ischemic stroke, stem cell therapy studies and their effects on neurogenesis, the most recent clinical trials, and techniques to track and monitor the progress of endogenous and exogenous stem cells.http://dx.doi.org/10.1155/2017/3267352 |
| spellingShingle | Cesar Reis Michael Wilkinson Haley Reis Onat Akyol Vadim Gospodarev Camila Araujo Sheng Chen John H. Zhang A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke Stem Cells International |
| title | A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke |
| title_full | A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke |
| title_fullStr | A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke |
| title_full_unstemmed | A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke |
| title_short | A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke |
| title_sort | look into stem cell therapy exploring the options for treatment of ischemic stroke |
| url | http://dx.doi.org/10.1155/2017/3267352 |
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