Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches
In recent years, medication-related osteonecrosis of the jaw (MRONJ) became an arising disease due to the important antiresorptive drug prescriptions to treat oncologic and osteoporotic patients, as well as the use of new antiangiogenic drugs such as VEGF antagonist. So far, MRONJ physiopathogenesis...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/8768162 |
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| author | Thomas Lombard Virginie Neirinckx Bernard Rogister Yves Gilon Sabine Wislet |
| author_facet | Thomas Lombard Virginie Neirinckx Bernard Rogister Yves Gilon Sabine Wislet |
| author_sort | Thomas Lombard |
| collection | DOAJ |
| description | In recent years, medication-related osteonecrosis of the jaw (MRONJ) became an arising disease due to the important antiresorptive drug prescriptions to treat oncologic and osteoporotic patients, as well as the use of new antiangiogenic drugs such as VEGF antagonist. So far, MRONJ physiopathogenesis still remains unclear. Aiming to better understand MRONJ physiopathology, the first objective of this review would be to highlight major molecular mechanisms that are known to be involved in bone formation and remodeling. Recent development in MRONJ pharmacological treatments showed good results; however, those treatments are not curative and could have major side effects. In parallel to pharmacological treatments, MSC grafts appeared to be beneficial in the treatment of MRONJ, in multiple aspects: (1) recruitment and stimulation of local or regional endogenous cells to differentiate into osteoblasts and thus bone formation, (2) beneficial impact on bone remodeling, and (3) immune-modulatory properties that decrease inflammation. In this context, the second objective of this manuscript would be to summarize the molecular regulatory events controlling osteogenic differentiation, bone remodeling, and osteoimmunology and potential beneficial effects of MSC related to those aspects, in order to apprehend MRONJ and to develop new therapeutic approaches. |
| format | Article |
| id | doaj-art-e92f602aa8eb4ceabae7fcefbbe80de0 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e92f602aa8eb4ceabae7fcefbbe80de02025-02-03T06:00:40ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/87681628768162Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic ApproachesThomas Lombard0Virginie Neirinckx1Bernard Rogister2Yves Gilon3Sabine Wislet4Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Liège, Liège, BelgiumLaboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Liège, Liège, BelgiumLaboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Liège, Liège, BelgiumDepartment of Maxillofacial Surgery, CHU, University of Liège, Liège, BelgiumLaboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Liège, Liège, BelgiumIn recent years, medication-related osteonecrosis of the jaw (MRONJ) became an arising disease due to the important antiresorptive drug prescriptions to treat oncologic and osteoporotic patients, as well as the use of new antiangiogenic drugs such as VEGF antagonist. So far, MRONJ physiopathogenesis still remains unclear. Aiming to better understand MRONJ physiopathology, the first objective of this review would be to highlight major molecular mechanisms that are known to be involved in bone formation and remodeling. Recent development in MRONJ pharmacological treatments showed good results; however, those treatments are not curative and could have major side effects. In parallel to pharmacological treatments, MSC grafts appeared to be beneficial in the treatment of MRONJ, in multiple aspects: (1) recruitment and stimulation of local or regional endogenous cells to differentiate into osteoblasts and thus bone formation, (2) beneficial impact on bone remodeling, and (3) immune-modulatory properties that decrease inflammation. In this context, the second objective of this manuscript would be to summarize the molecular regulatory events controlling osteogenic differentiation, bone remodeling, and osteoimmunology and potential beneficial effects of MSC related to those aspects, in order to apprehend MRONJ and to develop new therapeutic approaches.http://dx.doi.org/10.1155/2016/8768162 |
| spellingShingle | Thomas Lombard Virginie Neirinckx Bernard Rogister Yves Gilon Sabine Wislet Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches Stem Cells International |
| title | Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches |
| title_full | Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches |
| title_fullStr | Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches |
| title_full_unstemmed | Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches |
| title_short | Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches |
| title_sort | medication related osteonecrosis of the jaw new insights into molecular mechanisms and cellular therapeutic approaches |
| url | http://dx.doi.org/10.1155/2016/8768162 |
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