Primary Biliary Cirrhosis in A Patient with Turner Syndrome
An increased prevalence of X chromosome monosomy has recently been demonstrated in patients with primary biliary cirrhosis (PBC). Chronic cholestasis of unknown etiology is a common clinical feature in patients with Turner syndrome who reach the fourth and fifth decades of life. A 37-year-old patien...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2005/180515 |
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| _version_ | 1832565135557787648 |
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| author | Piotr Milkiewicz Jenny Heathcote |
| author_facet | Piotr Milkiewicz Jenny Heathcote |
| author_sort | Piotr Milkiewicz |
| collection | DOAJ |
| description | An increased prevalence of X chromosome monosomy has recently been demonstrated in patients with primary biliary cirrhosis (PBC). Chronic cholestasis of unknown etiology is a common clinical feature in patients with Turner syndrome who reach the fourth and fifth decades of life. A 37-year-old patient with Turner syndrome who presented with clinical and biochemical features of chronic cholestasis is described. Subsequent investigations confirmed the diagnosis of PBC. The patient did not respond to the medical treatment and was referred for liver transplant assessment. The present case may support the importance of X chromosome genes in the development of genetic predisposition to PBC, and emphasizes the necessity for a systematic study of the prevalence of PBC in patients with Turner syndrome. |
| format | Article |
| id | doaj-art-e92ed711d23541e99368b8616c3663d7 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-e92ed711d23541e99368b8616c3663d72025-02-03T01:09:11ZengWileyCanadian Journal of Gastroenterology0835-79002005-01-01191063163310.1155/2005/180515Primary Biliary Cirrhosis in A Patient with Turner SyndromePiotr Milkiewicz0Jenny Heathcote1Toronto Western Hospital, University Health Network, Toronto, Ontario, CanadaToronto Western Hospital, University Health Network, Toronto, Ontario, CanadaAn increased prevalence of X chromosome monosomy has recently been demonstrated in patients with primary biliary cirrhosis (PBC). Chronic cholestasis of unknown etiology is a common clinical feature in patients with Turner syndrome who reach the fourth and fifth decades of life. A 37-year-old patient with Turner syndrome who presented with clinical and biochemical features of chronic cholestasis is described. Subsequent investigations confirmed the diagnosis of PBC. The patient did not respond to the medical treatment and was referred for liver transplant assessment. The present case may support the importance of X chromosome genes in the development of genetic predisposition to PBC, and emphasizes the necessity for a systematic study of the prevalence of PBC in patients with Turner syndrome.http://dx.doi.org/10.1155/2005/180515 |
| spellingShingle | Piotr Milkiewicz Jenny Heathcote Primary Biliary Cirrhosis in A Patient with Turner Syndrome Canadian Journal of Gastroenterology |
| title | Primary Biliary Cirrhosis in A Patient with Turner Syndrome |
| title_full | Primary Biliary Cirrhosis in A Patient with Turner Syndrome |
| title_fullStr | Primary Biliary Cirrhosis in A Patient with Turner Syndrome |
| title_full_unstemmed | Primary Biliary Cirrhosis in A Patient with Turner Syndrome |
| title_short | Primary Biliary Cirrhosis in A Patient with Turner Syndrome |
| title_sort | primary biliary cirrhosis in a patient with turner syndrome |
| url | http://dx.doi.org/10.1155/2005/180515 |
| work_keys_str_mv | AT piotrmilkiewicz primarybiliarycirrhosisinapatientwithturnersyndrome AT jennyheathcote primarybiliarycirrhosisinapatientwithturnersyndrome |