Binary curcuminoid complex CRE-Bin inhibits osteoclast differentiation by suppressing the canonical NF-κB signaling pathway and modulating microRNA-223 expression

Binary curcuminoid complex CRE-Bin inhibits osteoclast differentiation by suppressing the canonical NF-κB signaling pathway and modulating microRNA-223 expression

Abstract Curcuminoids, the major bioactive compounds in Curcuma longa L., inhibit osteoclast differentiation—a key process in bone resorption. microRNA-223 regulates osteoclast differentiation by targeting nuclear factor I-A. How curcuminoids influence osteoclast differentiation through microRNA-223...

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Bibliographic Details
Main Authors: Sompot Jantarawong, Wipapan Khimmaktong, Piyawut Swangphon, Natda Lauterbach, Natthaphon Nanakorn, Pharkphoom Panichayupakaranant, Yutthana Pengjam
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Curcuminoid
Osteoclast differentiation
microRNA-223
Nuclear factor I-A
Canonical nuclear factor-κB signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-04314-8
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