Investigative needle core biopsies support multimodal deep-data generation in glioblastoma

Investigative needle core biopsies support multimodal deep-data generation in glioblastoma

Abstract Glioblastoma (GBM) is an aggressive primary brain cancer with few effective therapies. Stereotactic needle biopsies are routinely used for diagnosis; however, the feasibility and utility of investigative biopsies to monitor treatment response remains ill-defined. Here, we demonstrate the de...

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Main Authors: Kenny K. H. Yu, Sreyashi Basu, Gerard Baquer, Ryuhjin Ahn, Jennifer Gantchev, Sonali Jindal, Michael S. Regan, Zaki Abou-Mrad, Michael C. Prabhu, Marc J. Williams, Alicia D. D’Souza, Seth W. Malinowski, Kelsey Hopland, Yuval Elhanati, Sylwia A. Stopka, Alexei Stortchevoi, Charles Couturier, Zhong He, Jingjing Sun, Yulong Chen, Alexsandra B. Espejo, Kin Hoe Chow, Smitha Yerrum, Pei-Lun Kao, Brittany Parker Kerrigan, Lisa Norberg, Douglas Nielsen, The GBM TeamLab, Vinay K. Puduvalli, Jason Huse, Rameen Beroukhim, Betty Y. S. Kim, Sangeeta Goswami, Adrienne Boire, Sarah Frisken, Michael J. Cima, Matthias Holdhoff, Calixto-Hope G. Lucas, Chetan Bettegowda, Stuart S. Levine, Tejus A. Bale, Cameron Brennan, David A. Reardon, Frederick F. Lang, E. Antonio Chiocca, Keith L. Ligon, Forest M. White, Padmanee Sharma, Viviane Tabar, Nathalie Y. R. Agar
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58452-8
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