The mechanobiology of extracellular matrix: a focus on thrombospondins

The mechanobiology of extracellular matrix: a focus on thrombospondins

Abstract Mechanosensitive thrombospondins (TSPs), a class of extracellular matrix (ECM) glycoproteins, have garnered increasing attention for their pivotal roles in transducing mechanical cues into biochemical signals during tissue adaptation and disease progression. This review delineates the conte...

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Bibliographic Details
Main Authors: Ying Zhao, Ting Lei, Xin Ge, Liumeizi Fan, Yinbin He, Zhou Yu, Sheng Hu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
Thrombospondins
Mechano-transduction
Extracellular matrix
Cardiovascular system
Musculoskeletal system
Fibrotic tissues
Online Access:https://doi.org/10.1186/s12964-025-02365-y
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