Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy
Background: The role of neuroinflammation in epileptogenesis has been previously explored, and several biomarkers have been identified as being relevant in assessing the intensity of the inflammatory process. In human medicine, an increased C reactive protein (CRP) blood concentration and/or neutrop...
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MDPI AG
2024-09-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/11/9/408 |
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| author | Andreea Despa Mihai Musteata Gheorghe Solcan |
| author_facet | Andreea Despa Mihai Musteata Gheorghe Solcan |
| author_sort | Andreea Despa |
| collection | DOAJ |
| description | Background: The role of neuroinflammation in epileptogenesis has been previously explored, and several biomarkers have been identified as being relevant in assessing the intensity of the inflammatory process. In human medicine, an increased C reactive protein (CRP) blood concentration and/or neutrophil-to-lymphocyte ratio (NLR) is considered a constant finding of epileptic activity. In veterinary medicine, only a few studies have been published regarding both of these topics. Hypothesis/objectives: Our aim was to assess the C reactive protein blood concentration and the neutrophil-to-lymphocyte ratio in epileptic dogs, regardless of etiology. Method: This retrospective study was based on changes in routine blood parameters in 59 dogs with epileptic activity. Results: An increased C reactive protein concentration was observed mostly in the dogs affected by structural epilepsy, and all epileptic dogs displayed abnormal neutrophil-to-lymphocyte values. Conclusions: Based on the authors’ knowledge, this is the first report regarding the NLR in epileptic dogs. Both the CRP concentration and the NLR might be considered feasible non-specific markers of the neuroinflamation involved in epileptogenesis and might be used in the diagnosis of and therapeutic approach to cluster seizures in dogs with idiopathic epilepsy and in patients with structural epilepsy. Dogs diagnosed with IEis and high CRP concentrations and NLRs may be subject to non-documented cluster seizures. Both CRP and the NLR have limited diagnostic value in dogs with reactive seizures. |
| format | Article |
| id | doaj-art-e91baba29d4344de9a0e0a68e33ed3ea |
| institution | OA Journals |
| issn | 2306-7381 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
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| series | Veterinary Sciences |
| spelling | doaj-art-e91baba29d4344de9a0e0a68e33ed3ea2025-08-20T01:55:57ZengMDPI AGVeterinary Sciences2306-73812024-09-0111940810.3390/vetsci11090408Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine EpilepsyAndreea Despa0Mihai Musteata1Gheorghe Solcan2Neurology Service, Faculty of Veterinary Medicine, Ion Ionescu de la Brad Iași University of Life Sciences (IULS), 700489 Iași, RomaniaNeurology Service, Faculty of Veterinary Medicine, Ion Ionescu de la Brad Iași University of Life Sciences (IULS), 700489 Iași, RomaniaInternal Medicine Clinic, Faculty of Veterinary Medicine, Ion Ionescu de la Brad Iași University of Life Sciences (IULS), 700489 Iași, RomaniaBackground: The role of neuroinflammation in epileptogenesis has been previously explored, and several biomarkers have been identified as being relevant in assessing the intensity of the inflammatory process. In human medicine, an increased C reactive protein (CRP) blood concentration and/or neutrophil-to-lymphocyte ratio (NLR) is considered a constant finding of epileptic activity. In veterinary medicine, only a few studies have been published regarding both of these topics. Hypothesis/objectives: Our aim was to assess the C reactive protein blood concentration and the neutrophil-to-lymphocyte ratio in epileptic dogs, regardless of etiology. Method: This retrospective study was based on changes in routine blood parameters in 59 dogs with epileptic activity. Results: An increased C reactive protein concentration was observed mostly in the dogs affected by structural epilepsy, and all epileptic dogs displayed abnormal neutrophil-to-lymphocyte values. Conclusions: Based on the authors’ knowledge, this is the first report regarding the NLR in epileptic dogs. Both the CRP concentration and the NLR might be considered feasible non-specific markers of the neuroinflamation involved in epileptogenesis and might be used in the diagnosis of and therapeutic approach to cluster seizures in dogs with idiopathic epilepsy and in patients with structural epilepsy. Dogs diagnosed with IEis and high CRP concentrations and NLRs may be subject to non-documented cluster seizures. Both CRP and the NLR have limited diagnostic value in dogs with reactive seizures.https://www.mdpi.com/2306-7381/11/9/408C reactive proteinneutrophil-to-lymphocyte ratioepilepsyneuroinflammationinflammation markerscanine |
| spellingShingle | Andreea Despa Mihai Musteata Gheorghe Solcan Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy Veterinary Sciences C reactive protein neutrophil-to-lymphocyte ratio epilepsy neuroinflammation inflammation markers canine |
| title | Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy |
| title_full | Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy |
| title_fullStr | Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy |
| title_full_unstemmed | Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy |
| title_short | Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy |
| title_sort | evaluation of blood c reactive protein crp and neutrophil to lymphocyte ratio nlr utility in canine epilepsy |
| topic | C reactive protein neutrophil-to-lymphocyte ratio epilepsy neuroinflammation inflammation markers canine |
| url | https://www.mdpi.com/2306-7381/11/9/408 |
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