Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats
Gentamicin (GM) is a widely used antibiotic against serious and life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rats. Quan...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/390613 |
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| author | Pavle Randjelovic Slavimir Veljkovic Nenad Stojiljkovic Ljubinka Jankovic-Velickovic Dusan Sokolovic Milan Stoiljkovic Ivan Ilic |
| author_facet | Pavle Randjelovic Slavimir Veljkovic Nenad Stojiljkovic Ljubinka Jankovic-Velickovic Dusan Sokolovic Milan Stoiljkovic Ivan Ilic |
| author_sort | Pavle Randjelovic |
| collection | DOAJ |
| description | Gentamicin (GM) is a widely used antibiotic against serious and life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rats. Quantitative evaluation of gentamicin-induced structural alterations and degree of functional alterations in the kidneys were performed by histopathological and biochemical analyses in order to determine potential beneficial effects of SA coadministration with gentamicin. Gentamicin was observed to cause a severe nephrotoxicity which was evidenced by an elevation of serum urea and creatinine levels. The significant increases in malondialdehyde (MDA) levels and protein carbonyl groups indicated that GM-induced tissue injury was mediated through oxidative reactions. On the other hand, simultaneous SA administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GM treatment. Exposure to GM caused necrosis of tubular epithelial cells. Necrosis of tubules was found to be prevented by SA pretreatment. The results from our study indicate that SA supplement attenuates oxidative-stress associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats. |
| format | Article |
| id | doaj-art-e90ad4a7f1e146d4bad70851da702530 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e90ad4a7f1e146d4bad70851da7025302025-02-03T01:12:26ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/390613390613Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in RatsPavle Randjelovic0Slavimir Veljkovic1Nenad Stojiljkovic2Ljubinka Jankovic-Velickovic3Dusan Sokolovic4Milan Stoiljkovic5Ivan Ilic6Department of Physiology, Faculty of Medicine, University of Nis, 18000 Nis, SerbiaDepartment of Physiology, Faculty of Medicine, University of Nis, 18000 Nis, SerbiaDepartment of Physiology, Faculty of Medicine, University of Nis, 18000 Nis, SerbiaDepartment of Pathology, Faculty of Medicine, University of Nis, 18000 Nis, SerbiaDepartment of Biochemistry, Faculty of Medicine, University of Nis, 18000 Nis, SerbiaDepartment of Pharmacology, Faculty of Medicine, University of Nis, 18000 Nis, SerbiaDepartment of Pathology, Faculty of Medicine, University of Nis, 18000 Nis, SerbiaGentamicin (GM) is a widely used antibiotic against serious and life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rats. Quantitative evaluation of gentamicin-induced structural alterations and degree of functional alterations in the kidneys were performed by histopathological and biochemical analyses in order to determine potential beneficial effects of SA coadministration with gentamicin. Gentamicin was observed to cause a severe nephrotoxicity which was evidenced by an elevation of serum urea and creatinine levels. The significant increases in malondialdehyde (MDA) levels and protein carbonyl groups indicated that GM-induced tissue injury was mediated through oxidative reactions. On the other hand, simultaneous SA administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GM treatment. Exposure to GM caused necrosis of tubular epithelial cells. Necrosis of tubules was found to be prevented by SA pretreatment. The results from our study indicate that SA supplement attenuates oxidative-stress associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats.http://dx.doi.org/10.1100/2012/390613 |
| spellingShingle | Pavle Randjelovic Slavimir Veljkovic Nenad Stojiljkovic Ljubinka Jankovic-Velickovic Dusan Sokolovic Milan Stoiljkovic Ivan Ilic Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats The Scientific World Journal |
| title | Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats |
| title_full | Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats |
| title_fullStr | Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats |
| title_full_unstemmed | Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats |
| title_short | Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats |
| title_sort | salicylic acid attenuates gentamicin induced nephrotoxicity in rats |
| url | http://dx.doi.org/10.1100/2012/390613 |
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