Prenatal exposure to criteria air pollution and traffic-related air toxics and risk of autism spectrum disorder: A population-based cohort study of California births (1990–2018)
Background: Autism spectrum disorder (ASD) prevalence has risen steadily in California (CA) over several decades, with environmental factors like air pollution (AP) increasingly implicated. This study investigates associations between prenatal exposure to both criteria AP and traffic-related air tox...
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Elsevier
2025-07-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412025003137 |
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| author | Karl O’Sharkey Sanjali Mitra Ting Chow Seung-a Paik Laura Thompson Jason Su Myles Cockburn Beate Ritz |
| author_facet | Karl O’Sharkey Sanjali Mitra Ting Chow Seung-a Paik Laura Thompson Jason Su Myles Cockburn Beate Ritz |
| author_sort | Karl O’Sharkey |
| collection | DOAJ |
| description | Background: Autism spectrum disorder (ASD) prevalence has risen steadily in California (CA) over several decades, with environmental factors like air pollution (AP) increasingly implicated. This study investigates associations between prenatal exposure to both criteria AP and traffic-related air toxics and ASD risk for 1990–2018 births. Methods: Utilizing CA Department of Public Health birth registry data from 1990 to 2018, linked with ASD diagnoses from the CA Department of Developmental Services (n = 13,591,003 children; ASD cases = 138,460, identified from birth year through 2022, allowing for a follow-up ranging from a minimum of 4 to a maximum of 32 years) we assessed prenatal exposure to PM2.5, NO2, O3, and six traffic-related air toxics (benzene, 1,3-butadiene, chromium, lead, nickel, zinc) using machine learning-enhanced land-use regression models. Logistic regression estimated odds ratios (OR) for ASD per interquartile range increase in pollutant levels across four periods (1990–1997, 1998–2004, 2005–2011, 2012–2018). Additionally, analyses were stratified by race/ethnicity, area-level socioeconomic status (SES), and region. Results: Prenatal exposure to PM2.5 (OR:1.10; 95% CI: 1.04, 1.17) and NO2 (OR:1.25; 95% CI:1.16, 1.35) were associated with increased ASD risk, with effect sizes declining over time. When mutually adjusting for NO2, the association between PM2.5 exposure and ASD risk was attenuated, whereas the association with NO2 exposure remained largely unchanged. Among air toxics, benzene (OR:1.55; 95% CI:1.51, 1.59) and nickel (OR:1.32; 95% CI:1.21, 1.45) were strongly associated with ASD, associations persisting across time. Stratified analyses revealed that associations differed by race/ethnicity, SES, and region. Air toxics consistently exhibited elevated ASD risks, highlighting persistent vulnerabilities despite reductions in criteria pollutants. Conclusions: Prenatal/early-life exposure to AP, especially traffic-related toxics, is linked to increased ASD risk with temporal and spatial variability. While reductions in NO2 and PM2.5 lessen ASD risk, persistent associations with traffic-related pollutants like benzene and nickel highlight the need for targeted interventions. |
| format | Article |
| id | doaj-art-e909461fc32b4f1b85ebde0cf4e4249b |
| institution | Kabale University |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
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| series | Environment International |
| spelling | doaj-art-e909461fc32b4f1b85ebde0cf4e4249b2025-08-20T03:30:44ZengElsevierEnvironment International0160-41202025-07-0120110956210.1016/j.envint.2025.109562Prenatal exposure to criteria air pollution and traffic-related air toxics and risk of autism spectrum disorder: A population-based cohort study of California births (1990–2018)Karl O’Sharkey0Sanjali Mitra1Ting Chow2Seung-a Paik3Laura Thompson4Jason Su5Myles Cockburn6Beate Ritz7Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USADepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USADepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USADepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USADepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032, USADivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USADepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032, USADepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Corresponding author at: Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.Background: Autism spectrum disorder (ASD) prevalence has risen steadily in California (CA) over several decades, with environmental factors like air pollution (AP) increasingly implicated. This study investigates associations between prenatal exposure to both criteria AP and traffic-related air toxics and ASD risk for 1990–2018 births. Methods: Utilizing CA Department of Public Health birth registry data from 1990 to 2018, linked with ASD diagnoses from the CA Department of Developmental Services (n = 13,591,003 children; ASD cases = 138,460, identified from birth year through 2022, allowing for a follow-up ranging from a minimum of 4 to a maximum of 32 years) we assessed prenatal exposure to PM2.5, NO2, O3, and six traffic-related air toxics (benzene, 1,3-butadiene, chromium, lead, nickel, zinc) using machine learning-enhanced land-use regression models. Logistic regression estimated odds ratios (OR) for ASD per interquartile range increase in pollutant levels across four periods (1990–1997, 1998–2004, 2005–2011, 2012–2018). Additionally, analyses were stratified by race/ethnicity, area-level socioeconomic status (SES), and region. Results: Prenatal exposure to PM2.5 (OR:1.10; 95% CI: 1.04, 1.17) and NO2 (OR:1.25; 95% CI:1.16, 1.35) were associated with increased ASD risk, with effect sizes declining over time. When mutually adjusting for NO2, the association between PM2.5 exposure and ASD risk was attenuated, whereas the association with NO2 exposure remained largely unchanged. Among air toxics, benzene (OR:1.55; 95% CI:1.51, 1.59) and nickel (OR:1.32; 95% CI:1.21, 1.45) were strongly associated with ASD, associations persisting across time. Stratified analyses revealed that associations differed by race/ethnicity, SES, and region. Air toxics consistently exhibited elevated ASD risks, highlighting persistent vulnerabilities despite reductions in criteria pollutants. Conclusions: Prenatal/early-life exposure to AP, especially traffic-related toxics, is linked to increased ASD risk with temporal and spatial variability. While reductions in NO2 and PM2.5 lessen ASD risk, persistent associations with traffic-related pollutants like benzene and nickel highlight the need for targeted interventions.http://www.sciencedirect.com/science/article/pii/S0160412025003137Autism spectrum disorderAir pollutionPM2.5NO2Traffic-related air toxicsPrenatal exposure |
| spellingShingle | Karl O’Sharkey Sanjali Mitra Ting Chow Seung-a Paik Laura Thompson Jason Su Myles Cockburn Beate Ritz Prenatal exposure to criteria air pollution and traffic-related air toxics and risk of autism spectrum disorder: A population-based cohort study of California births (1990–2018) Environment International Autism spectrum disorder Air pollution PM2.5 NO2 Traffic-related air toxics Prenatal exposure |
| title | Prenatal exposure to criteria air pollution and traffic-related air toxics and risk of autism spectrum disorder: A population-based cohort study of California births (1990–2018) |
| title_full | Prenatal exposure to criteria air pollution and traffic-related air toxics and risk of autism spectrum disorder: A population-based cohort study of California births (1990–2018) |
| title_fullStr | Prenatal exposure to criteria air pollution and traffic-related air toxics and risk of autism spectrum disorder: A population-based cohort study of California births (1990–2018) |
| title_full_unstemmed | Prenatal exposure to criteria air pollution and traffic-related air toxics and risk of autism spectrum disorder: A population-based cohort study of California births (1990–2018) |
| title_short | Prenatal exposure to criteria air pollution and traffic-related air toxics and risk of autism spectrum disorder: A population-based cohort study of California births (1990–2018) |
| title_sort | prenatal exposure to criteria air pollution and traffic related air toxics and risk of autism spectrum disorder a population based cohort study of california births 1990 2018 |
| topic | Autism spectrum disorder Air pollution PM2.5 NO2 Traffic-related air toxics Prenatal exposure |
| url | http://www.sciencedirect.com/science/article/pii/S0160412025003137 |
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