Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation?
Ischemia reperfusion injury (IRI) is an inevitable clinical consequence in organ transplantation. It can lead to early graft nonfunction and contribute to acute and chronic graft rejection. Advanced molecular biology has revealed the highly complex nature of this phenomenon and few definitive therap...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/819382 |
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| author | Arunotai Siriussawakul Lucinda I. Chen John D. Lang |
| author_facet | Arunotai Siriussawakul Lucinda I. Chen John D. Lang |
| author_sort | Arunotai Siriussawakul |
| collection | DOAJ |
| description | Ischemia reperfusion injury (IRI) is an inevitable clinical consequence in organ transplantation. It can lead to early graft nonfunction and contribute to acute and chronic graft rejection. Advanced molecular biology has revealed the highly complex nature of this phenomenon and few definitive therapies exist. This paper reviews factors involved in the pathophysiology of IRI and potential ways to attenuate it. In recent years, inhaled nitric oxide, carbon monoxide, and hydrogen sulfide have been increasingly explored as plausible novel medical gases that can attenuate IRI via multiple mechanisms, including microvascular vasorelaxation, reduced inflammation, and mitochondrial modulation. Here, we review recent advances in research utilizing inhaled nitric oxide, carbon monoxide, and hydrogen sulfide in animal and human studies of IRI and postulate on its future applications specific to solid organ transplantation. |
| format | Article |
| id | doaj-art-e9021d8f76d54f03bc5a2e3e17c7679c |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-e9021d8f76d54f03bc5a2e3e17c7679c2025-02-03T01:20:50ZengWileyJournal of Transplantation2090-00072090-00152012-01-01201210.1155/2012/819382819382Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation?Arunotai Siriussawakul0Lucinda I. Chen1John D. Lang2Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Anesthesiology and Pain Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USADepartment of Anesthesiology and Pain Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USAIschemia reperfusion injury (IRI) is an inevitable clinical consequence in organ transplantation. It can lead to early graft nonfunction and contribute to acute and chronic graft rejection. Advanced molecular biology has revealed the highly complex nature of this phenomenon and few definitive therapies exist. This paper reviews factors involved in the pathophysiology of IRI and potential ways to attenuate it. In recent years, inhaled nitric oxide, carbon monoxide, and hydrogen sulfide have been increasingly explored as plausible novel medical gases that can attenuate IRI via multiple mechanisms, including microvascular vasorelaxation, reduced inflammation, and mitochondrial modulation. Here, we review recent advances in research utilizing inhaled nitric oxide, carbon monoxide, and hydrogen sulfide in animal and human studies of IRI and postulate on its future applications specific to solid organ transplantation.http://dx.doi.org/10.1155/2012/819382 |
| spellingShingle | Arunotai Siriussawakul Lucinda I. Chen John D. Lang Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? Journal of Transplantation |
| title | Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? |
| title_full | Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? |
| title_fullStr | Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? |
| title_full_unstemmed | Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? |
| title_short | Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? |
| title_sort | medical gases a novel strategy for attenuating ischemia reperfusion injury in organ transplantation |
| url | http://dx.doi.org/10.1155/2012/819382 |
| work_keys_str_mv | AT arunotaisiriussawakul medicalgasesanovelstrategyforattenuatingischemiareperfusioninjuryinorgantransplantation AT lucindaichen medicalgasesanovelstrategyforattenuatingischemiareperfusioninjuryinorgantransplantation AT johndlang medicalgasesanovelstrategyforattenuatingischemiareperfusioninjuryinorgantransplantation |