COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling Pathway
ABSTRACT Copper metabolism MURR1 domain protein 10 (COMMD10) regulates numerous biological processes that are essential for cellular homeostasis. However, the role of COMMD10 in angiogenesis and bone formation remains unexplored. We constructed a COMMD10 knockdown model in endothelial cells and dete...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | FASEB BioAdvances |
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| Online Access: | https://doi.org/10.1096/fba.2024-00159 |
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| author | Peiran Li Yanxi Li |
| author_facet | Peiran Li Yanxi Li |
| author_sort | Peiran Li |
| collection | DOAJ |
| description | ABSTRACT Copper metabolism MURR1 domain protein 10 (COMMD10) regulates numerous biological processes that are essential for cellular homeostasis. However, the role of COMMD10 in angiogenesis and bone formation remains unexplored. We constructed a COMMD10 knockdown model in endothelial cells and determined the influence of COMMD10 on angiogenesis and bone formation. Our results indicate that COMMD10 knockdown enhances vascular formation by influencing the expression of genes and proteins related to angiogenesis in endothelial cells. In addition, endothelial cells expressing low levels of COMMD10 facilitate bone formation by secreting pro‐osteogenic factors. Further, the Rap1 signaling pathway is activated under low COMMD10 conditions. Double knockdown of RAP1B and COMMD10 attenuated the angiogenic ability of endothelial cells. In summary, our research demonstrates that low COMMD10 expression promotes angiogenesis and bone formation through the Rap1 signaling pathway. |
| format | Article |
| id | doaj-art-e8f1a5e72baf49e587db46a88842e7f0 |
| institution | Kabale University |
| issn | 2573-9832 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | FASEB BioAdvances |
| spelling | doaj-art-e8f1a5e72baf49e587db46a88842e7f02025-08-20T03:46:04ZengWileyFASEB BioAdvances2573-98322025-06-0176n/an/a10.1096/fba.2024-00159COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling PathwayPeiran Li0Yanxi Li1Department of Plastic and Traumatic Surgery School of Stomatology, Beijing Stomatological Hospital, Capital Medical University Beijing ChinaDepartment of Dental Implant Center School of Stomatology, Beijing Stomatological Hospital, Capital Medical University Beijing ChinaABSTRACT Copper metabolism MURR1 domain protein 10 (COMMD10) regulates numerous biological processes that are essential for cellular homeostasis. However, the role of COMMD10 in angiogenesis and bone formation remains unexplored. We constructed a COMMD10 knockdown model in endothelial cells and determined the influence of COMMD10 on angiogenesis and bone formation. Our results indicate that COMMD10 knockdown enhances vascular formation by influencing the expression of genes and proteins related to angiogenesis in endothelial cells. In addition, endothelial cells expressing low levels of COMMD10 facilitate bone formation by secreting pro‐osteogenic factors. Further, the Rap1 signaling pathway is activated under low COMMD10 conditions. Double knockdown of RAP1B and COMMD10 attenuated the angiogenic ability of endothelial cells. In summary, our research demonstrates that low COMMD10 expression promotes angiogenesis and bone formation through the Rap1 signaling pathway.https://doi.org/10.1096/fba.2024-00159angiogenesisbone formationCOMMD10endothelial cellsRap1 |
| spellingShingle | Peiran Li Yanxi Li COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling Pathway FASEB BioAdvances angiogenesis bone formation COMMD10 endothelial cells Rap1 |
| title | COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling Pathway |
| title_full | COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling Pathway |
| title_fullStr | COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling Pathway |
| title_full_unstemmed | COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling Pathway |
| title_short | COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling Pathway |
| title_sort | commd10 regulates angiogenesis and bone formation via rap1 signaling pathway |
| topic | angiogenesis bone formation COMMD10 endothelial cells Rap1 |
| url | https://doi.org/10.1096/fba.2024-00159 |
| work_keys_str_mv | AT peiranli commd10regulatesangiogenesisandboneformationviarap1signalingpathway AT yanxili commd10regulatesangiogenesisandboneformationviarap1signalingpathway |