Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma
Aim. To investigate the expressions of glutathione peroxidase 1 (GPX1) and caudal-related homeodomain transcription factor (CDX2) in GAC and their correlation with clinicopathological features and tumor cell proliferation. Methods. The expressions of GPX1, CDX2, and Ki67 were immunohistochemically e...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/380193 |
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| author | Jing Jing Han De Rong Xie Li Li Wang Ye Qing Liu Gong Fa Wu Qing Sun Yan Xian Chen Ying Wei Zhi Quan Huang Hai Gang Li |
| author_facet | Jing Jing Han De Rong Xie Li Li Wang Ye Qing Liu Gong Fa Wu Qing Sun Yan Xian Chen Ying Wei Zhi Quan Huang Hai Gang Li |
| author_sort | Jing Jing Han |
| collection | DOAJ |
| description | Aim. To investigate the expressions of glutathione peroxidase 1 (GPX1) and caudal-related homeodomain transcription factor (CDX2) in GAC and their correlation with clinicopathological features and tumor cell proliferation. Methods. The expressions of GPX1, CDX2, and Ki67 were immunohistochemically evaluated in 172 GAC specimens. The association of GPX1 and CDX2 with patient’s clinicopathological features and Ki67 positive rate was analyzed statistically. Results. In 172 cases of GAC, the expression of GPX1 was weaker than that in adjacent normal mucosa, and the expression of CDX2 was higher than that in adjacent normal mucosa. High expression GPX1 strong-expression was associated with differentiation, Lauren type, WHO type and extensive lymph node metastasis of GAC. High expression of CDX2 was associated with differentiation, Lauren type, WHO type, extensive lymph node metastasis, and TNM of GAC. Survival curves showed that expressions of GPX1 and CDX2 were factors of good outcome ( and .02, resp.). According to multivariate analysis, only lymph node metastasis, TNM stage, and CDX2 expression were independently associated with survival. In addition, a strong association of GPX1 expression was noted with Ki67 and CDX2. Conclusions. The expression of GPX1 and CDX2 may play a role in the carcinogenesis, differentiation, and progression of GAC, and CDX2 may be an independent prognostic factor. |
| format | Article |
| id | doaj-art-e8f09cd2e17d43d7aee226e767955509 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e8f09cd2e17d43d7aee226e7679555092025-02-03T01:11:01ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/380193380193Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric AdenocarcinomaJing Jing Han0De Rong Xie1Li Li Wang2Ye Qing Liu3Gong Fa Wu4Qing Sun5Yan Xian Chen6Ying Wei7Zhi Quan Huang8Hai Gang Li9Department of Pathology, Zengcheng People’s Hospital, Zengcheng City 511300, ChinaDepartment of Oncology, Sun Yat-Sen Memorial Hospital, Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen University, Guangzhou 510120, ChinaDepartment of Pathology, Sun Yat-Sen Memorial Hospital, Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen University, Guangzhou 510120, ChinaDepartment of Pathology, Zengcheng People’s Hospital, Zengcheng City 511300, ChinaDepartment of Pathology, Zengcheng People’s Hospital, Zengcheng City 511300, ChinaDepartment of Pathology, Sun Yat-Sen Memorial Hospital, Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen University, Guangzhou 510120, ChinaDepartment of Oncology, Sun Yat-Sen Memorial Hospital, Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen University, Guangzhou 510120, ChinaDepartment of Oncology, Sun Yat-Sen Memorial Hospital, Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen University, Guangzhou 510120, ChinaDepartment of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital, Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen University, Guangzhou 510120, ChinaDepartment of Pathology, Zengcheng People’s Hospital, Zengcheng City 511300, ChinaAim. To investigate the expressions of glutathione peroxidase 1 (GPX1) and caudal-related homeodomain transcription factor (CDX2) in GAC and their correlation with clinicopathological features and tumor cell proliferation. Methods. The expressions of GPX1, CDX2, and Ki67 were immunohistochemically evaluated in 172 GAC specimens. The association of GPX1 and CDX2 with patient’s clinicopathological features and Ki67 positive rate was analyzed statistically. Results. In 172 cases of GAC, the expression of GPX1 was weaker than that in adjacent normal mucosa, and the expression of CDX2 was higher than that in adjacent normal mucosa. High expression GPX1 strong-expression was associated with differentiation, Lauren type, WHO type and extensive lymph node metastasis of GAC. High expression of CDX2 was associated with differentiation, Lauren type, WHO type, extensive lymph node metastasis, and TNM of GAC. Survival curves showed that expressions of GPX1 and CDX2 were factors of good outcome ( and .02, resp.). According to multivariate analysis, only lymph node metastasis, TNM stage, and CDX2 expression were independently associated with survival. In addition, a strong association of GPX1 expression was noted with Ki67 and CDX2. Conclusions. The expression of GPX1 and CDX2 may play a role in the carcinogenesis, differentiation, and progression of GAC, and CDX2 may be an independent prognostic factor.http://dx.doi.org/10.1155/2013/380193 |
| spellingShingle | Jing Jing Han De Rong Xie Li Li Wang Ye Qing Liu Gong Fa Wu Qing Sun Yan Xian Chen Ying Wei Zhi Quan Huang Hai Gang Li Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma Gastroenterology Research and Practice |
| title | Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma |
| title_full | Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma |
| title_fullStr | Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma |
| title_full_unstemmed | Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma |
| title_short | Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma |
| title_sort | significance of glutathione peroxidase 1 and caudal related homeodomain transcription factor in human gastric adenocarcinoma |
| url | http://dx.doi.org/10.1155/2013/380193 |
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