Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study
Abstract The regional differences in cerebral oxygen extraction fraction (OEF) in brain were investigated using positron emission tomography (PET) in detail with consideration of systemic errors in PET measurement estimated by simulation studies. The cerebral blood flow (CBF), cerebral blood volume...
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| Language: | English |
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Elsevier
2023-10-01
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| Series: | Journal of Physiological Sciences |
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| Online Access: | https://doi.org/10.1186/s12576-023-00880-6 |
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| author | Hiroshi Ito Masanobu Ibaraki Ryo Yamakuni Motoharu Hakozaki Naoyuki Ukon Shiro Ishii Kenji Fukushima Hitoshi Kubo Kazuhiro Takahashi |
| author_facet | Hiroshi Ito Masanobu Ibaraki Ryo Yamakuni Motoharu Hakozaki Naoyuki Ukon Shiro Ishii Kenji Fukushima Hitoshi Kubo Kazuhiro Takahashi |
| author_sort | Hiroshi Ito |
| collection | DOAJ |
| description | Abstract The regional differences in cerebral oxygen extraction fraction (OEF) in brain were investigated using positron emission tomography (PET) in detail with consideration of systemic errors in PET measurement estimated by simulation studies. The cerebral blood flow (CBF), cerebral blood volume (CBV), OEF, and cerebral metabolic rate of oxygen (CMRO2) were measured on healthy men by PET with 15O-labeled gases. The OEF values in the pons and the parahippocampal gyrus were significantly smaller than in the other brain regions. The OEF value in the lateral side of the occipital cortex was largest among the cerebral cortical regions. Simulation studies have revealed that errors in OEF caused by regional differences in the distribution volume of 15O-labeled water, as well as errors in OEF caused by a mixture of gray and white matter, must be negligible. The regional differences in OEF in brain must exist which might be related to physiological meanings.Article title: Kindly check and confirm the edit made in the article title.I have checked the article title and it is OK as is. Trial registration: The UMIN clinical trial number: UMIN000033382, https://www.umin.ac.jp/ctr/index.htm |
| format | Article |
| id | doaj-art-e8f03ced45434adcb233fbbcee5aaa04 |
| institution | Kabale University |
| issn | 1880-6562 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Physiological Sciences |
| spelling | doaj-art-e8f03ced45434adcb233fbbcee5aaa042025-08-20T03:24:37ZengElsevierJournal of Physiological Sciences1880-65622023-10-0173111110.1186/s12576-023-00880-6Oxygen extraction fraction is not uniform in human brain: a positron emission tomography studyHiroshi Ito0Masanobu Ibaraki1Ryo Yamakuni2Motoharu Hakozaki3Naoyuki Ukon4Shiro Ishii5Kenji Fukushima6Hitoshi Kubo7Kazuhiro Takahashi8Department of Radiology and Nuclear Medicine, Fukushima Medical UniversityDepartment of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood VesselsDepartment of Radiology and Nuclear Medicine, Fukushima Medical UniversityDepartment of Radiology and Nuclear Medicine, Fukushima Medical UniversityAdvanced Clinical Research Center, Fukushima Medical UniversityDepartment of Radiology and Nuclear Medicine, Fukushima Medical UniversityDepartment of Radiology and Nuclear Medicine, Fukushima Medical UniversitySchool of Medical Sciences, Fukushima Medical UniversityAdvanced Clinical Research Center, Fukushima Medical UniversityAbstract The regional differences in cerebral oxygen extraction fraction (OEF) in brain were investigated using positron emission tomography (PET) in detail with consideration of systemic errors in PET measurement estimated by simulation studies. The cerebral blood flow (CBF), cerebral blood volume (CBV), OEF, and cerebral metabolic rate of oxygen (CMRO2) were measured on healthy men by PET with 15O-labeled gases. The OEF values in the pons and the parahippocampal gyrus were significantly smaller than in the other brain regions. The OEF value in the lateral side of the occipital cortex was largest among the cerebral cortical regions. Simulation studies have revealed that errors in OEF caused by regional differences in the distribution volume of 15O-labeled water, as well as errors in OEF caused by a mixture of gray and white matter, must be negligible. The regional differences in OEF in brain must exist which might be related to physiological meanings.Article title: Kindly check and confirm the edit made in the article title.I have checked the article title and it is OK as is. Trial registration: The UMIN clinical trial number: UMIN000033382, https://www.umin.ac.jp/ctr/index.htmhttps://doi.org/10.1186/s12576-023-00880-6BrainCBFCMRO2OEFPET |
| spellingShingle | Hiroshi Ito Masanobu Ibaraki Ryo Yamakuni Motoharu Hakozaki Naoyuki Ukon Shiro Ishii Kenji Fukushima Hitoshi Kubo Kazuhiro Takahashi Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study Journal of Physiological Sciences Brain CBF CMRO2 OEF PET |
| title | Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study |
| title_full | Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study |
| title_fullStr | Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study |
| title_full_unstemmed | Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study |
| title_short | Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study |
| title_sort | oxygen extraction fraction is not uniform in human brain a positron emission tomography study |
| topic | Brain CBF CMRO2 OEF PET |
| url | https://doi.org/10.1186/s12576-023-00880-6 |
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