Improving diagnostic accuracy in atypical melanocytic tumors using p16 immunohistochemistry and 9p21 fluorescence in situ hybridization: analysis of 206 second opinion cases

Improving diagnostic accuracy in atypical melanocytic tumors using p16 immunohistochemistry and 9p21 fluorescence in situ hybridization: analysis of 206 second opinion cases

Abstract Diagnosing atypical melanocytic tumors can be challenging without molecular characterization, necessitating simple tools to enhance diagnostic accuracy in daily practice. This study retrospectively analyzed the utility of p16 immunohistochemistry (IHC) and 9p21 fluorescence in situ hybridiz...

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Main Authors: Rémi Vergara, Elodie Laharanne, Arnaud de la Fouchardière, Audrey Gros, Jean-Philippe Merlio, Mathilde Guyon, Caroline Dutriaux, Marie Beylot-Barry, Béatrice Vergier, Fanny Beltzung
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
p16
FISH
Ambiguous melanocytic tumour
Melanoma
Naevus
Second opinion
Online Access:https://doi.org/10.1038/s41598-025-95785-2
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