Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogens
Context: Infectious diseases are the leading cause of death in developing countries like India. Hence, even small relative increases in the mortality rate for infections due to multidrug-resistant pathogens would lead to substantial increases in the number of deaths as a result of infections worldwi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-11-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_680_24 |
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| author | Chandra Sekhar Talari Sree Ravi Shankar Calerappa Geethanjali Anke |
| author_facet | Chandra Sekhar Talari Sree Ravi Shankar Calerappa Geethanjali Anke |
| author_sort | Chandra Sekhar Talari Sree |
| collection | DOAJ |
| description | Context:
Infectious diseases are the leading cause of death in developing countries like India. Hence, even small relative increases in the mortality rate for infections due to multidrug-resistant pathogens would lead to substantial increases in the number of deaths as a result of infections worldwide.
Aims:
The aim of the study was to study the microbiological data of community-acquired pathogens and the corresponding outcomes due to antibiotic-resistant versus antibiotic-susceptible bacterial microorganisms.
Settings and Design:
A single-center prospective cohort study for two years undertaken during the study period of March 2022 to 31 October 2023.
Materials and Methods:
All clinical samples of 402 patients diagnosed microbiologically as community-acquired infections were included. Culture samples were collected and processed according to standard operating procedures and clinical details were recorded.
Statistical Analysis Used:
Categorical variables were expressed as counts and percentages. Fisher’s exact test was used for testing differences in proportions. Two-sided distribution P values of <0.05 were considered significant.
Results:
Among Gram-positive organisms, Staphylococcus aureus and Streptococcus pyogenes were predominant isolates. Escherichia coli and Klebsiella species were the majority of the pathogens among Gram-negative isolates. Mortality rates observed in community-acquired respiratory tract infections (CA-RTIs), community-acquired urinary tract infections (CA-UTIs), community-acquired skin and soft tissue infections (CA-SSTIs), and community-acquired bloodstream infections (CA-BSIs) were 13.6%, 6.56%, 4.5%, and 31.5%, respectively. The length of hospital stay of more than three days was found as 56.06%, 36.2%, 40.9%, and 73.6% in CA-RTIs, CA-UTIs, CA-SSTIs, and CA-BSIs, respectively.
Conclusions:
Performing cultures earlier during hospitalization and determining the timing of colonization can allow more targeted choices and reduce morbidity and mortality rates among infected patients. |
| format | Article |
| id | doaj-art-e8e5dc211cb341a7ba6fbba4fe2a5500 |
| institution | DOAJ |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-e8e5dc211cb341a7ba6fbba4fe2a55002025-08-20T02:39:24ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352024-11-0113115052505910.4103/jfmpc.jfmpc_680_24Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogensChandra Sekhar Talari SreeRavi Shankar CalerappaGeethanjali AnkeContext: Infectious diseases are the leading cause of death in developing countries like India. Hence, even small relative increases in the mortality rate for infections due to multidrug-resistant pathogens would lead to substantial increases in the number of deaths as a result of infections worldwide. Aims: The aim of the study was to study the microbiological data of community-acquired pathogens and the corresponding outcomes due to antibiotic-resistant versus antibiotic-susceptible bacterial microorganisms. Settings and Design: A single-center prospective cohort study for two years undertaken during the study period of March 2022 to 31 October 2023. Materials and Methods: All clinical samples of 402 patients diagnosed microbiologically as community-acquired infections were included. Culture samples were collected and processed according to standard operating procedures and clinical details were recorded. Statistical Analysis Used: Categorical variables were expressed as counts and percentages. Fisher’s exact test was used for testing differences in proportions. Two-sided distribution P values of <0.05 were considered significant. Results: Among Gram-positive organisms, Staphylococcus aureus and Streptococcus pyogenes were predominant isolates. Escherichia coli and Klebsiella species were the majority of the pathogens among Gram-negative isolates. Mortality rates observed in community-acquired respiratory tract infections (CA-RTIs), community-acquired urinary tract infections (CA-UTIs), community-acquired skin and soft tissue infections (CA-SSTIs), and community-acquired bloodstream infections (CA-BSIs) were 13.6%, 6.56%, 4.5%, and 31.5%, respectively. The length of hospital stay of more than three days was found as 56.06%, 36.2%, 40.9%, and 73.6% in CA-RTIs, CA-UTIs, CA-SSTIs, and CA-BSIs, respectively. Conclusions: Performing cultures earlier during hospitalization and determining the timing of colonization can allow more targeted choices and reduce morbidity and mortality rates among infected patients.https://journals.lww.com/10.4103/jfmpc.jfmpc_680_24community-acquired infectionsmultidrug-resistant bacteria |
| spellingShingle | Chandra Sekhar Talari Sree Ravi Shankar Calerappa Geethanjali Anke Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogens Journal of Family Medicine and Primary Care community-acquired infections multidrug-resistant bacteria |
| title | Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogens |
| title_full | Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogens |
| title_fullStr | Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogens |
| title_full_unstemmed | Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogens |
| title_short | Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogens |
| title_sort | aerobic bacteria study clinical spectrum and outcome of patients with community acquired multidrug resistant pathogens |
| topic | community-acquired infections multidrug-resistant bacteria |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_680_24 |
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