Methods of creation of bladder cancer models and their application in preclinical studies (literature review)
Purpose of the study to summarize available data on methods for creating bladder cancer models for their application in preclinical studies.Material and methods. A systematic literature search was conducted in the Elibrary, Pubmed, Googlescholar, CyberLeninka databases.Results. The review shows curr...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2022-05-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/2099 |
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| _version_ | 1849341244657893376 |
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| author | I. A. Kamaeva A. S. Goncharova E. A. Lukbanova |
| author_facet | I. A. Kamaeva A. S. Goncharova E. A. Lukbanova |
| author_sort | I. A. Kamaeva |
| collection | DOAJ |
| description | Purpose of the study to summarize available data on methods for creating bladder cancer models for their application in preclinical studies.Material and methods. A systematic literature search was conducted in the Elibrary, Pubmed, Googlescholar, CyberLeninka databases.Results. The review shows current data on various bladder cancer models and their application in practice. Bladder cancer pathology, identification of diagnostic markers and the development of new therapies are of the main challenges facing the management of bladder cancer. To solve these problems, it is often necessary to conduct preclinical studies using experimental models.Conclusion. Bladder cancer models that can fully reproduce a human disease in terms of histology and behavior are necessary to study the factors involved in cancer development, progression and metastasis. For this, various experimental models are currently used. Human tumor xenografts in mice are widely used. They can reproduce the main pathophysiological features of cancer biology. However, it is necessary to clearly present all the pros and cons of the selected experimental models. The literature review presents modern data on the etiology of bladder cancer, results of preclinical studies on various experimental models, including orthotopic and heterotopic xenografts. |
| format | Article |
| id | doaj-art-e8e31b7a5d4f4d3097652aa567883621 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-e8e31b7a5d4f4d3097652aa5678836212025-08-20T03:43:40ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682022-05-0121214314910.21294/1814-4861-2022-21-2-143-149988Methods of creation of bladder cancer models and their application in preclinical studies (literature review)I. A. Kamaeva0A. S. Goncharova1E. A. Lukbanova2National Medical Research Center of Oncology of the Ministry of Health of Russia National Medical Research Center of Oncology of the Ministry of Health of Russia National Medical Research Center of Oncology of the Ministry of Health of Russia Purpose of the study to summarize available data on methods for creating bladder cancer models for their application in preclinical studies.Material and methods. A systematic literature search was conducted in the Elibrary, Pubmed, Googlescholar, CyberLeninka databases.Results. The review shows current data on various bladder cancer models and their application in practice. Bladder cancer pathology, identification of diagnostic markers and the development of new therapies are of the main challenges facing the management of bladder cancer. To solve these problems, it is often necessary to conduct preclinical studies using experimental models.Conclusion. Bladder cancer models that can fully reproduce a human disease in terms of histology and behavior are necessary to study the factors involved in cancer development, progression and metastasis. For this, various experimental models are currently used. Human tumor xenografts in mice are widely used. They can reproduce the main pathophysiological features of cancer biology. However, it is necessary to clearly present all the pros and cons of the selected experimental models. The literature review presents modern data on the etiology of bladder cancer, results of preclinical studies on various experimental models, including orthotopic and heterotopic xenografts.https://www.siboncoj.ru/jour/article/view/2099bladder cancerxenographtorthotopic tumor modelsimmunodeficiency micepreclinical studies |
| spellingShingle | I. A. Kamaeva A. S. Goncharova E. A. Lukbanova Methods of creation of bladder cancer models and their application in preclinical studies (literature review) Сибирский онкологический журнал bladder cancer xenographt orthotopic tumor models immunodeficiency mice preclinical studies |
| title | Methods of creation of bladder cancer models and their application in preclinical studies (literature review) |
| title_full | Methods of creation of bladder cancer models and their application in preclinical studies (literature review) |
| title_fullStr | Methods of creation of bladder cancer models and their application in preclinical studies (literature review) |
| title_full_unstemmed | Methods of creation of bladder cancer models and their application in preclinical studies (literature review) |
| title_short | Methods of creation of bladder cancer models and their application in preclinical studies (literature review) |
| title_sort | methods of creation of bladder cancer models and their application in preclinical studies literature review |
| topic | bladder cancer xenographt orthotopic tumor models immunodeficiency mice preclinical studies |
| url | https://www.siboncoj.ru/jour/article/view/2099 |
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