Host cellular protein RAB33B facilitates influenza viral replication and modulates M2 trafficking by enhancing autophagy

Host cellular protein RAB33B facilitates influenza viral replication and modulates M2 trafficking by enhancing autophagy

Abstract Influenza A virus (IAV) remains a major global health threat. Its M2 protein plays crucial roles in viral fusion, transportation, assembly, and release. Recent studies have shown that IAV impairs host autophagy flux to enhance viral replication. However, the precise mechanisms by which IAV...

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Bibliographic Details
Main Authors: Shaotang Ye, Zhen Wang, Gang Lu, Aolei Chen, Liang Xu, Yongbo Liu, Jianwei Mao, Jingyu Wang, Gaoming Lou, Qingmei Xie, Kun Jia, Shoujun Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Veterinary Research
Subjects:
IAV
M2 protein
autophagy
RAB33B
host–pathogen interaction
membrane trafficking
Online Access:https://doi.org/10.1186/s13567-025-01560-6
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