Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release.
C. elegans undergoes periods of behavioral quiescence during larval molts (termed lethargus) and as adults. Little is known about the circuit mechanisms that establish these quiescent states. Lethargus and adult locomotion quiescence is dramatically reduced in mutants lacking the neuropeptide recept...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-07-01
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| Series: | PLoS Genetics |
| Online Access: | https://doi.org/10.1371/journal.pgen.1005359 |
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| author | Seungwon Choi Kelsey P Taylor Marios Chatzigeorgiou Zhitao Hu William R Schafer Joshua M Kaplan |
| author_facet | Seungwon Choi Kelsey P Taylor Marios Chatzigeorgiou Zhitao Hu William R Schafer Joshua M Kaplan |
| author_sort | Seungwon Choi |
| collection | DOAJ |
| description | C. elegans undergoes periods of behavioral quiescence during larval molts (termed lethargus) and as adults. Little is known about the circuit mechanisms that establish these quiescent states. Lethargus and adult locomotion quiescence is dramatically reduced in mutants lacking the neuropeptide receptor NPR-1. Here, we show that the aroused locomotion of npr-1 mutants results from the exaggerated activity in multiple classes of sensory neurons, including nociceptive (ASH), touch sensitive (ALM and PLM), and stretch sensing (DVA) neurons. These sensory neurons accelerate locomotion via both neuropeptide and glutamate release. The relative contribution of these sensory neurons to arousal differs between larval molts and adults. Our results suggest that a broad network of sensory neurons dictates transitions between aroused and quiescent behavioral states. |
| format | Article |
| id | doaj-art-e8dae61ccef540a4a08b48caa985cff9 |
| institution | DOAJ |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-e8dae61ccef540a4a08b48caa985cff92025-08-20T03:10:07ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042015-07-01117e100535910.1371/journal.pgen.1005359Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release.Seungwon ChoiKelsey P TaylorMarios ChatzigeorgiouZhitao HuWilliam R SchaferJoshua M KaplanC. elegans undergoes periods of behavioral quiescence during larval molts (termed lethargus) and as adults. Little is known about the circuit mechanisms that establish these quiescent states. Lethargus and adult locomotion quiescence is dramatically reduced in mutants lacking the neuropeptide receptor NPR-1. Here, we show that the aroused locomotion of npr-1 mutants results from the exaggerated activity in multiple classes of sensory neurons, including nociceptive (ASH), touch sensitive (ALM and PLM), and stretch sensing (DVA) neurons. These sensory neurons accelerate locomotion via both neuropeptide and glutamate release. The relative contribution of these sensory neurons to arousal differs between larval molts and adults. Our results suggest that a broad network of sensory neurons dictates transitions between aroused and quiescent behavioral states.https://doi.org/10.1371/journal.pgen.1005359 |
| spellingShingle | Seungwon Choi Kelsey P Taylor Marios Chatzigeorgiou Zhitao Hu William R Schafer Joshua M Kaplan Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release. PLoS Genetics |
| title | Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release. |
| title_full | Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release. |
| title_fullStr | Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release. |
| title_full_unstemmed | Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release. |
| title_short | Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release. |
| title_sort | sensory neurons arouse c elegans locomotion via both glutamate and neuropeptide release |
| url | https://doi.org/10.1371/journal.pgen.1005359 |
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