The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor
Fibroblast growth factors (FGFs) are classically known as hormonal factors and recent studies have revealed that FGFs have a key role in regulating growth and development of several reproductive organs, including the testis. The testis is mainly consisted of germ cells, Sertoli cells and Leydig cell...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/489095 |
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| author | Xin Jiang Melissa Skibba Chi Zhang Yi Tan Ying Xin Yaqin Qu |
| author_facet | Xin Jiang Melissa Skibba Chi Zhang Yi Tan Ying Xin Yaqin Qu |
| author_sort | Xin Jiang |
| collection | DOAJ |
| description | Fibroblast growth factors (FGFs) are classically known as hormonal factors and recent studies have revealed that FGFs have a key role in regulating growth and development of several reproductive organs, including the testis. The testis is mainly consisted of germ cells, Sertoli cells and Leydig cells to develop and maintain the male phenotype and reproduction. This review summarizes the structure and fuctions of testis, the roles of FGFs on testicular development and potential involvement in testicular tumor and its regulatory mechanism. Among 23 members of FGFs, the FGF-1, FGF-2, FGF-4, FGF-8, FGF-9, and FGF-21 were involved and describe in details. Understanding the roles and mechanism of FGFs is the foundation to modeling testicular development and treatments in testicular disease. Therefore, in the last part, the potential therapy with FGFs for the testis of cancer and diabetes was also discussed. |
| format | Article |
| id | doaj-art-e8d616e33a614f8ba6ea52704b13723b |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e8d616e33a614f8ba6ea52704b13723b2025-02-03T05:52:40ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/489095489095The Roles of Fibroblast Growth Factors in the Testicular Development and TumorXin Jiang0Melissa Skibba1Chi Zhang2Yi Tan3Ying Xin4Yaqin Qu5The First Hospital of Jilin University, Changchun 130021, ChinaKCHRI at the Department of Pediatrics, The University of Louisville, Louisville 40202, USAKCHRI at the Department of Pediatrics, The University of Louisville, Louisville 40202, USAKCHRI at the Department of Pediatrics, The University of Louisville, Louisville 40202, USAKCHRI at the Department of Pediatrics, The University of Louisville, Louisville 40202, USAThe First Hospital of Jilin University, Changchun 130021, ChinaFibroblast growth factors (FGFs) are classically known as hormonal factors and recent studies have revealed that FGFs have a key role in regulating growth and development of several reproductive organs, including the testis. The testis is mainly consisted of germ cells, Sertoli cells and Leydig cells to develop and maintain the male phenotype and reproduction. This review summarizes the structure and fuctions of testis, the roles of FGFs on testicular development and potential involvement in testicular tumor and its regulatory mechanism. Among 23 members of FGFs, the FGF-1, FGF-2, FGF-4, FGF-8, FGF-9, and FGF-21 were involved and describe in details. Understanding the roles and mechanism of FGFs is the foundation to modeling testicular development and treatments in testicular disease. Therefore, in the last part, the potential therapy with FGFs for the testis of cancer and diabetes was also discussed.http://dx.doi.org/10.1155/2013/489095 |
| spellingShingle | Xin Jiang Melissa Skibba Chi Zhang Yi Tan Ying Xin Yaqin Qu The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor Journal of Diabetes Research |
| title | The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor |
| title_full | The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor |
| title_fullStr | The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor |
| title_full_unstemmed | The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor |
| title_short | The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor |
| title_sort | roles of fibroblast growth factors in the testicular development and tumor |
| url | http://dx.doi.org/10.1155/2013/489095 |
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