Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series
Synthesis of β-hydroxysulfides of 1,3-dioxepane series and their further functionalization were performed. Chiral β-hydroxysulfides were separated into enantiomers using enzymatic acylation by lipase PS. Study of antifungal activity of the obtained compounds showed that some enantiomerically pure 6-...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/3589342 |
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| author | Roman S. Pavelyev Rusalia M. Vafina Konstantin V. Balakin Oleg I. Gnezdilov Aleksey B. Dobrynin Olga A. Lodochnikova Rashid Z. Musin Galina A. Chmutova Svetlana A. Lisovskaya Liliya E. Nikitina |
| author_facet | Roman S. Pavelyev Rusalia M. Vafina Konstantin V. Balakin Oleg I. Gnezdilov Aleksey B. Dobrynin Olga A. Lodochnikova Rashid Z. Musin Galina A. Chmutova Svetlana A. Lisovskaya Liliya E. Nikitina |
| author_sort | Roman S. Pavelyev |
| collection | DOAJ |
| description | Synthesis of β-hydroxysulfides of 1,3-dioxepane series and their further functionalization were performed. Chiral β-hydroxysulfides were separated into enantiomers using enzymatic acylation by lipase PS. Study of antifungal activity of the obtained compounds showed that some enantiomerically pure 6-arylthio-1,3-dioxepan-5-ols represent promising antifungal drug candidates. |
| format | Article |
| id | doaj-art-e8d01ec389d74868938a8c8626f57210 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e8d01ec389d74868938a8c8626f572102025-02-03T01:21:30ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/35893423589342Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane SeriesRoman S. Pavelyev0Rusalia M. Vafina1Konstantin V. Balakin2Oleg I. Gnezdilov3Aleksey B. Dobrynin4Olga A. Lodochnikova5Rashid Z. Musin6Galina A. Chmutova7Svetlana A. Lisovskaya8Liliya E. Nikitina9Kazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan E. K. Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, Sibirsky Tract, 10/7, Kazan 420029, RussiaA.E. Arbuzov Institute of Organic and Physical Chemistry; KazSC, Russian Academy of Sciences, Arbuzova 8, Kazan 420088, RussiaA.E. Arbuzov Institute of Organic and Physical Chemistry; KazSC, Russian Academy of Sciences, Arbuzova 8, Kazan 420088, RussiaA.E. Arbuzov Institute of Organic and Physical Chemistry; KazSC, Russian Academy of Sciences, Arbuzova 8, Kazan 420088, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan Scientific and Research Institute of Epidemiology and Microbiology, Bolshaya Krasnaya 67, Kazan 420015, RussiaKazan State Medical University, Butlerova 49, Kazan 420012, RussiaSynthesis of β-hydroxysulfides of 1,3-dioxepane series and their further functionalization were performed. Chiral β-hydroxysulfides were separated into enantiomers using enzymatic acylation by lipase PS. Study of antifungal activity of the obtained compounds showed that some enantiomerically pure 6-arylthio-1,3-dioxepan-5-ols represent promising antifungal drug candidates.http://dx.doi.org/10.1155/2018/3589342 |
| spellingShingle | Roman S. Pavelyev Rusalia M. Vafina Konstantin V. Balakin Oleg I. Gnezdilov Aleksey B. Dobrynin Olga A. Lodochnikova Rashid Z. Musin Galina A. Chmutova Svetlana A. Lisovskaya Liliya E. Nikitina Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series Journal of Chemistry |
| title | Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series |
| title_full | Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series |
| title_fullStr | Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series |
| title_full_unstemmed | Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series |
| title_short | Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series |
| title_sort | synthesis and antifungal activity of β hydroxysulfides of 1 3 dioxepane series |
| url | http://dx.doi.org/10.1155/2018/3589342 |
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