Histone demethylases in autophagy and inflammation
Abstract Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only wit...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Cell Communication and Signaling |
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| Online Access: | https://doi.org/10.1186/s12964-024-02006-w |
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| author | Yaoyao Ma Wenting Lv Yi Guo Tong Yin Yujie Bai Ziqi Liu Chao Chen WenjuanYang Jiayi Feng Wenbin Qian Ruiling Tang Yanting Su Shigang Shan Huifen Dong Yongfen Bao Lihua Qu |
| author_facet | Yaoyao Ma Wenting Lv Yi Guo Tong Yin Yujie Bai Ziqi Liu Chao Chen WenjuanYang Jiayi Feng Wenbin Qian Ruiling Tang Yanting Su Shigang Shan Huifen Dong Yongfen Bao Lihua Qu |
| author_sort | Yaoyao Ma |
| collection | DOAJ |
| description | Abstract Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only with oncogenesis but also with inflammatory responses. Among post-translational modifications, histone lysine methylation holds significant importance. There are over 30 members of histone lysine demethylases (KDMs), which act as epigenetic regulators in physiological processes and diseases. Importantly, KDMs are abnormally expressed in the regulation of cellular autophagy and inflammation, representing a crucial mechanism affecting inflammation-related diseases. This article reviewed the function of KDMs proteins in autophagy and inflammation. Specifically, It focused on the specific regulatory mechanisms underlying the activation or inhibition of autophagy, as well as their abnormal expression in inflammatory responses. By analyzing each KDM in epigenetic modification, this review provides a reliable theoretical basis for clinical decision marking regarding autophagy abnormalities and inflammatory diseases. |
| format | Article |
| id | doaj-art-e8bb82a48f44442a894930be3795aaf4 |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-e8bb82a48f44442a894930be3795aaf42025-01-19T12:33:04ZengBMCCell Communication and Signaling1478-811X2025-01-0123112310.1186/s12964-024-02006-wHistone demethylases in autophagy and inflammationYaoyao Ma0Wenting Lv1Yi Guo2Tong Yin3Yujie Bai4Ziqi Liu5Chao Chen6WenjuanYang7Jiayi Feng8Wenbin Qian9Ruiling Tang10Yanting Su11Shigang Shan12Huifen Dong13Yongfen Bao14Lihua Qu15Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Hubei University of Science and Technology3Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan UniversitySchool of Basic Medical Sciences, Hubei University of Science and Technology3Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan UniversityDepartment of Scientific Research and Education, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College3Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan UniversitySchool of Medicine, Nanjing University of Chinese Medicine3Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University3Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan UniversityHubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Hubei University of Science and TechnologyHubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Hubei University of Science and TechnologyHubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Hubei University of Science and TechnologySchool of Public Health and Nursing, Hubei University of Science and Technology3Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan UniversitySchool of Basic Medical Sciences, Hubei University of Science and TechnologySchool of Basic Medical Sciences, Hubei University of Science and TechnologyAbstract Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only with oncogenesis but also with inflammatory responses. Among post-translational modifications, histone lysine methylation holds significant importance. There are over 30 members of histone lysine demethylases (KDMs), which act as epigenetic regulators in physiological processes and diseases. Importantly, KDMs are abnormally expressed in the regulation of cellular autophagy and inflammation, representing a crucial mechanism affecting inflammation-related diseases. This article reviewed the function of KDMs proteins in autophagy and inflammation. Specifically, It focused on the specific regulatory mechanisms underlying the activation or inhibition of autophagy, as well as their abnormal expression in inflammatory responses. By analyzing each KDM in epigenetic modification, this review provides a reliable theoretical basis for clinical decision marking regarding autophagy abnormalities and inflammatory diseases.https://doi.org/10.1186/s12964-024-02006-wHistone demethylasesAutophagyInflammation |
| spellingShingle | Yaoyao Ma Wenting Lv Yi Guo Tong Yin Yujie Bai Ziqi Liu Chao Chen WenjuanYang Jiayi Feng Wenbin Qian Ruiling Tang Yanting Su Shigang Shan Huifen Dong Yongfen Bao Lihua Qu Histone demethylases in autophagy and inflammation Cell Communication and Signaling Histone demethylases Autophagy Inflammation |
| title | Histone demethylases in autophagy and inflammation |
| title_full | Histone demethylases in autophagy and inflammation |
| title_fullStr | Histone demethylases in autophagy and inflammation |
| title_full_unstemmed | Histone demethylases in autophagy and inflammation |
| title_short | Histone demethylases in autophagy and inflammation |
| title_sort | histone demethylases in autophagy and inflammation |
| topic | Histone demethylases Autophagy Inflammation |
| url | https://doi.org/10.1186/s12964-024-02006-w |
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